PTPRB Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all PTPRB Proteins
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PTPRB protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human PTPRB (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PTPRB Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
- Alternative Name
- Ptprb (PTPRB Products)
- Synonyms
- PTPRB Protein, HPTP-BETA Protein, HPTPB Protein, PTPB Protein, R-PTP-BETA Protein, VEPTP Protein, 3230402H02Rik Protein, C130094E24 Protein, Ptpz Protein, Rptpb Protein, VE-PTP Protein, Veptp Protein, protein tyrosine phosphatase, receptor type B Protein, receptor-type tyrosine-protein phosphatase beta Protein, protein tyrosine phosphatase, receptor type, B Protein, PTPRB Protein, LOC100380677 Protein, Ptprb Protein
- Background
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 249 kDa
- NCBI Accession
- NP_001103224
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