UGT1A1 Protein (Myc-DYKDDDDK Tag)
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- Target See all UGT1A1 Proteins
- UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This UGT1A1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human UGT1A1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product UGT1A1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
- Alternative Name
- Ugt1a1 (UGT1A1 Products)
- Synonyms
- BILIQTL1 Protein, GNT1 Protein, HUG-BR1 Protein, UDPGT Protein, UDPGT 1-1 Protein, UGT1 Protein, UGT1A Protein, Gnt1 Protein, UGT1A01 Protein, Udpgt-1a Protein, UgtBr1 Protein, Udpgt Protein, Ugt1 Protein, zgc:123097 Protein, UDP glucuronosyltransferase family 1 member A1 Protein, UDP glucuronosyltransferase 1 family, polypeptide A1 Protein, UDP-glucuronosyltransferase 1-1 Protein, UDP-glucuronosyltransferase Protein, UDP-glucuronosyltransferase 1-6 Protein, UDP glucuronosyltransferase 1 family polypeptide a1 Protein, UGT1A1 Protein, Ugt1a1 Protein, LOC100065342 Protein, LOC100125517 Protein, LOC100229734 Protein, LOC100405984 Protein, LOC100511479 Protein, ugt1a1 Protein
- Background
- This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5&apos exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
- Molecular Weight
- 57.1 kDa
- NCBI Accession
- NP_000454
- Pathways
- Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha
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