AIMP1 Protein
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- Target See all AIMP1 Proteins
- AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Functional Studies (Func)
- Sequence
- SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK
- Characteristics
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/mL, corresponding to a specific activity of ＞ 2.5 x 104 IU/mg.
- Purity
- >98 % as determined by SDS-PAGE and HPLC.
- Sterility
- 0.2 μm filtered
- Top Product
- Discover our top product AIMP1 Protein
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Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1) (AA 2-312) protein (His tag)
AIMP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1) (AA 2-310) protein (His tag)AIMP1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1) (AA 1-312) protein (GST tag)AIMP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1) (AA 1-336) protein (His tag)AIMP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))
- Alternative Name
- AIMP1 (AIMP1 Products)
- Synonyms
- EMAP2 Protein, EMAPII Protein, HLD3 Protein, SCYE1 Protein, p43 Protein, wu:fa95a05 Protein, zgc:154081 Protein, AIMP1 Protein, 9830137A06Rik Protein, AIMP1/p43 Protein, Emap2 Protein, Scye1 Protein, scye1 Protein, aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Protein, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Protein, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 S homeolog Protein, AIMP1 Protein, aimp1 Protein, Aimp1 Protein, aimp1.S Protein
- Background
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Relevance: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}.
Synonyms: Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, EMAP-II, Small i, - Molecular Weight
- 18.2 kDa
- UniProt
- Q12904
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