PSME3 Protein (PSME3) (AA 2-254) (His tag)
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- Target See all PSME3 Proteins
- PSME3
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-254
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PSME3 protein is labelled with His tag.
- Sequence
- AA 2-254
- Characteristics
- This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30.3 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE).
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PSME3 Protein
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PSME3 (PSME3) (AA 1-267) protein (His tag)
PSME3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
PSME3 (PSME3) (AA 2-254) protein (His tag)PSME3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
PSME3 (PSME3) (AA 1-254) protein (His tag)PSME3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
PSME3 (PSME3) (AA 1-254) protein (GST tag)PSME3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
PSME3 (PSME3) (AA 2-254) protein (His tag)Crystallography grade PSME3 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
PSME3 (PSME3) (AA 2-252), (partial) protein (GST tag)PSME3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
PSME3 (PSME3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PSME3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- PSME3
- Alternative Name
- PSME3 (PSME3 Products)
- Synonyms
- AA410043 Protein, AU020960 Protein, Ki Protein, PA28gamma Protein, REGgamma Protein, pa28g Protein, Ab2-371 Protein, PA28-gamma Protein, PA28G Protein, REG-GAMMA Protein, psme3b Protein, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Protein, proteasome activator subunit 3 Protein, proteasome activator subunit 3 S homeolog Protein, Psme3 Protein, PSME3 Protein, psme3.S Protein
- Background
- Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
- Molecular Weight
- 30.3 kDa
- NCBI Accession
- NP_005780
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
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