Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PSME3 Protein (PSME3) (partial) (His tag)

PSME3 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE. WB
Catalog No. ABIN5608460
  • Target See all PSME3 Proteins
    PSME3
    Protein Type
    Recombinant
    Protein Characteristics
    partial
    Origin
    • 7
    • 1
    • 1
    • 1
    Human
    Source
    • 5
    • 3
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This PSME3 protein is labelled with His tag.
    Application
    Western Blotting (WB)
    Sequence
    Met 1 - Tyr 254
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Endotoxin level is less than 1.0 EU per ug by the LAL method.
    Top Product
    Discover our top product PSME3 Protein
  • Application Notes
    This recombinant protein can be used for WB.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 200 mM NaCl, pH 8.0
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
  • Target
    PSME3
    Alternative Name
    PSME3 (PSME3 Products)
    Synonyms
    AA410043 Protein, AU020960 Protein, Ki Protein, PA28gamma Protein, REGgamma Protein, pa28g Protein, Ab2-371 Protein, PA28-gamma Protein, PA28G Protein, REG-GAMMA Protein, psme3b Protein, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Protein, proteasome activator subunit 3 Protein, proteasome activator subunit 3 S homeolog Protein, Psme3 Protein, PSME3 Protein, psme3.S Protein
    Background
    Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
    Molecular Weight
    30.3 kDa
    Gene ID
    10197
    NCBI Accession
    NP_00578
    UniProt
    P61289
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
You are here:
Support