PVRL2 Protein (AA 32-360) (Fc Tag)
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- Target See all PVRL2 Proteins
- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 32-360
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PVRL2 protein is labelled with Fc Tag.
- Application
- Functional Studies (Func)
- Sequence
- AA 32-360
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 62.2 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PVRL2 Protein
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Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (His-Avi Tag)
PVRL2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-351) protein (His tag)PVRL2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) protein (Fc Tag)PVRL2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) protein (His-Avi Tag,Biotin)PVRL2 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (His tag)PVRL2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 32-360) (Active) protein (Fc Tag,AVI tag,Biotin)PVRL2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 43-182) protein (His tag)PVRL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) protein (GST tag)PVRL2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) protein (His tag)PVRL2 Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (Active) protein (His tag)PVRL2 Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
- Alternative Name
- Nectin-2 (PVRL2 Products)
- Synonyms
- prr2 Protein, AI325026 Protein, AI987993 Protein, Cd112 Protein, MPH Protein, Pvr Protein, Pvs Protein, nectin-2 Protein, CD112 Protein, HVEB Protein, PRR2 Protein, PVRR2 Protein, nectin cell adhesion molecule 2 Protein, Nectin2 Protein, NECTIN2 Protein
- Background
- Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
- Molecular Weight
- 62.2 kDa
- NCBI Accession
- NP_002847
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
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