CBX7 Protein (AA 1-251, full length) (His tag)
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- Target See all CBX7 Proteins
- CBX7 (Chromobox Homolog 7 (CBX7))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-251, full length
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CBX7 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK F
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product CBX7 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- CBX7 (Chromobox Homolog 7 (CBX7))
- Alternative Name
- CBX7 (CBX7 Products)
- Synonyms
- 1600014J01Rik Protein, AI851678 Protein, D15Ertd417e Protein, zgc:110152 Protein, chromobox 7 Protein, chromobox homolog 7a Protein, CBX7 Protein, Cbx7 Protein, cbx7a Protein
- Background
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin rodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
- Molecular Weight
- 32.4 kDa
- UniProt
- O95931
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