PDPK1 Protein (AA 29-436) (His tag)
-
- Target See all PDPK1 Proteins
- PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 29-436
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PDPK1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- PDK1, 29-436aa, Human, His-tagged, Recombinant, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product PDPK1 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20 mM Tris-HCl buffer (pH 7.0) containing 100mM NaCl, 0.5mM DTT, 0.1mM EDTA, 0.1mM PMSF, 1mM MgCl2, 40% glycerol
- Storage
- 4 °C
-
- Target
- PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
- Alternative Name
- PDK1 (PDPK1 Products)
- Synonyms
- pdpk1 Protein, MGC82080 Protein, PDK1 Protein, PDPK2 Protein, PRO0461 Protein, Pdk1 Protein, zgc:153787 Protein, 3'-phosphoinositide-dependent protein kinase 1 Protein, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 Protein, ATPDK1 Protein, AtPDK1 Protein, T32M21.110 Protein, T32M21_110 Protein, zgc:77318 Protein, 3-phosphoinositide dependent protein kinase 1 Protein, 3-phosphoinositide dependent protein kinase 1 L homeolog Protein, 3-phosphoinositide dependent protein kinase-1 Protein, 3-phosphoinositide dependent protein kinase 1a Protein, 3-phosphoinositide-dependent protein kinase 1 Protein, 3'-phosphoinositide-dependent protein kinase 1 Protein, 3-phosphoinositide dependent protein kinase 1b Protein, PDPK1 Protein, pdpk1.L Protein, pdpk1 Protein, Pdpk1 Protein, pdpk1a Protein, LOC100380750 Protein, pdk-1 Protein, PDK1 Protein, pdpk1b Protein
- Background
- PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Pyruvate dehydrogenase kinase, isozyme 1, Pyruvate dehydrogenase kinase, isozyme 1 HGNC:8809, Mitochondrial pyruvate dehydrogenase kinase isoenzyme1, PDK1, Pyruvate dehydrogenase kinase isoform 1, Pyruvate dehydrogenase kinase, isoenzyme 1. NCBI no.: NP_002601
- Molecular Weight
- 48.6 kDa (429 aa)
- Pathways
- PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
-