CrkL Protein (pTry207) (His tag)
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- Target See all CrkL (CRKL) Proteins
- CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
- Protein Type
- Recombinant
- Protein Characteristics
- pTry207
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CrkL protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- CRKL, 1-303aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS – PAGE
- Top Product
- Discover our top product CRKL Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
- Storage
- 4 °C
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- Target
- CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
- Alternative Name
- CRKL (CRKL Products)
- Synonyms
- CRKL Protein, wu:fa55g05 Protein, wu:fj60e01 Protein, zgc:63469 Protein, 1110025F07Rik Protein, AA589403 Protein, AI325100 Protein, Crkol Protein, CRK like proto-oncogene, adaptor protein Protein, v-crk avian sarcoma virus CT10 oncogene homolog-like Protein, CRKL Protein, crkl Protein, Crkl Protein
- Background
- CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substitutete of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and has oncogenic potential. Recombinant human CRKL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Crk-like protein,. NCBI no.: NP_005198
- Molecular Weight
- 35.9 kDa (323aa), confirmed by MALDI-TOF
- Pathways
- Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor
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