KPNA2 Protein (AA 1-529) (His tag)

Catalog No. ABIN667661

Product Details

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Protein Type: Recombinant

Protein Characteristics: AA 1-529

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KPNA2 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: KPNA2, 1-529aa, Human, His tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT

Storage: 4 °C

Target Details

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Alternative Name: KPNA2 (KPNA2 Products)

Synonyms: IPOA1 Protein, QIP2 Protein, RCH1 Protein, SRP1alpha Protein, ima2 Protein, importin Protein, 2410044B12Rik Protein, PTAC58 Protein, Rch1 Protein, ipoa1 Protein, kpna2 Protein, qip2 Protein, rch1 Protein, srp1alpha Protein, hm:zeh0389 Protein, hm:zeh0389r Protein, zgc:113902 Protein, zgc:86945 Protein, karyopherin subunit alpha 2 Protein, importin subunit alpha-2 Protein, Importin subunit alpha-2 Protein, karyopherin (importin) alpha 2 Protein, karyopherin alpha-2 subunit like L homeolog Protein, karyopherin alpha 2 (RAG cohort 1, importin alpha 1) Protein, KPNA2 Protein, EDI_246290 Protein, EDI_335040 Protein, ima2 Protein, Kpna2 Protein, kpna2.L Protein, kpna2 Protein

Background: Karyopherin alpha2 (KPNA2) is a member of the karyopherin alpha family. This protein plays a key role in the nuclear import of proteins with a classical nuclear localization signal (NLS). KPNA2 bound in vitro specifically and directly to substrates containing either a simple or bipartite NLS motif. It promoted docking of import substrates to the nuclear envelope and together with recombinant human Ran reconstituted complete nuclear protein import. Recombinant human KPNA2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Importin subunit alpha-2, IPOA1, QIP2, SRP1alpha. NCBI no.: AAH05978

Molecular Weight: 60.5 kDa (553aa)

Pathways: M Phase, Protein targeting to Nucleus