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Human alpha Actinin 4 ELISA Kit for Sandwich ELISA - ABIN577547
Van Raemdonck, Tjalma, Coen, Depuydt, Van Ostade: Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid. in PLoS ONE 2014
ACTN4 is a transcriptional coactivator of NF-kappaB (show NFKB1 ELISA Kits).
UCHL1 (show UCHL1 ELISA Kits) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (show FANCB ELISA Kits) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (show ACTN1 ELISA Kits) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR ELISA Kits).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (show NPHS1 ELISA Kits)-supported slit diaphragm complex.
nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement
High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.
Our findings indicate that ACTN4 promotes EMT (show ITK ELISA Kits) and tumorigenesis by regulating Snail (show SNAI1 ELISA Kits) expression and the Akt (show AKT1 ELISA Kits) pathway in cervical cancer. We propose a novel mechanism for EMT (show ITK ELISA Kits) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
SERPINE1 (show SERPINE1 ELISA Kits), ANGPLT4, CCL20 (show CCL20 ELISA Kits), and SAA1 (show SAA1 ELISA Kits) as well as the NF-kappaB (show NFKB1 ELISA Kits) (p65 (show GORASP1 ELISA Kits)) binding sites on GR-transrepressed promoters such as IL-1beta (show IL1B ELISA Kits), IL-6 (show IL6 ELISA Kits), and IL-8 (show IL8 ELISA Kits) Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
Here, we report the identification of a novel, disease-causing ACTN4 mutation (p.G195D, de novo) in a sporadic case of childhood FSGS using next generation sequencing.
the calmodulin domain of human alpha-actinin-4 binding to the linker region was important for regulating the distance between actin and actin-binding domain.
This study identified alpha-actinin-4 as a novel NHERF1 (show SLC9A3R1 ELISA Kits) interaction partner and provided new insights into the regulatory mechanism of the actin cytoskeleton by NHERF1 (show SLC9A3R1 ELISA Kits).
Selective regulation of NF-kappaB (show NFKB1 ELISA Kits) gene targets may indicate involvement of ACTN4 in determining the specificity of cell response to NF-kappaB (show NFKB1 ELISA Kits) activation in cells of different types. (Review)
ZYX (show ZYX ELISA Kits) defective binding to ACTN4, which occupies focal adhesions instead of ACTN1 (show ACTN1 ELISA Kits), induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.
The contribution of ACTN4 to the process of lung cancer metastasis to the brain could be mainly through regulation of actin cytoskeleton reorganization, cell motility, and focal adhesion.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1