Browse our SLC9A3 Proteins (SLC9A3)

Full name:
Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Proteins (SLC9A3)
On www.antibodies-online.com are 6 Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) Proteins from 3 different suppliers available. Additionally we are shipping SLC9A3 Antibodies (153) and SLC9A3 Kits (7) and many more products for this protein. A total of 169 SLC9A3 products are currently listed.
Synonyms:
9030624O13Rik, AI930210, NHE-3, Nhe3, SLC9A3
list all proteins Gene Name GeneID UniProt
SLC9A3 105243  
SLC9A3 24784 P26433
SLC9A3 6550 P48764

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SLC9A3 Proteins (SLC9A3) by Origin

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More Proteins for SLC9A3 Interaction Partners

Cow (Bovine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) interaction partners

  1. The expression of NHE3 in the rumen of sheep and cattle and its role in sodium transport are reported.

Rabbit Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) interaction partners

  1. Lysophosphatidic acid stimulation of NHE3 exocytosis includes a signaling pathway that regulates fixation of NHE3 to the microvillar cytoskeleton.

  2. 1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt (show AKT1 Proteins) and GSK-3, which act on a Ser (show SIGLEC1 Proteins) cluster in the same NHE3 C-terminal domain that binds ezrin (show EZR Proteins)

  3. CaMKII (show CAMK2G Proteins) binding to and phosphorylation of the NHE3 C terminus are parts of the physiologic regulation of NHE3 that occurs in fibroblasts as well as in the brush border of an intestinal Na(+)-absorptive cell.

  4. Regulation of NHE3 depends on the nature of the NHERF (show SLC9A3R1 Proteins) family member associating with NHE3 and the accompanying NHE3 complexes.

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) interaction partners

  1. NHERF1 (show SLC9A3R2 Proteins) mediates ANG II (show AGT Proteins)-induced activation of renal NHE3, which requires coordination between IRBIT (show AHCYL1 Proteins) and the NHERF1 (show SLC9A3R2 Proteins) PDZ1 domain in binding and transporting NHE3

  2. This study suggested an important role for NHE3 in generating the H(+) gradient that drives DMT1 (show SLC11A2 Proteins)-mediated iron uptake at the intestinal brush border.

  3. The Slc9a3-deficient mice with impaired male excurrent ducts in this study provide proof for our clinical findings that some Taiwanese of CBAVD carry SLC9A3 deletion but without major CFTR (show CFTR Proteins) mutations.

  4. Data suggest that increased phosphorylation of Nhe3/Slc9a3 accompanies gallstone formation and leads to increased turnover of the exchanger, resulting in decreased concentrating function of the gallbladder epithelium.

  5. hepcidin (show HAMP Proteins) is one of the promising therapeutic agents for calcium malabsorption in beta-thalassemia. It mainly stimulates the transcellular calcium transport across the duodenal epithelium in an NHE3-dependent manner.

  6. azilsartan (but not candesartan) improved salt sensitivity possibly by decreasing NHE3 expression via ubiquitin-proteasomal degradation.

  7. NHE3 in proximal tubules of the kidney, along with NHE3 in intestines, is required for maintaining basal blood pressure as well as the full development of ANG II (show AGT Proteins)-induced hypertension.

  8. Inflammation-induced loss of PDZK1 (show PDZK1 Proteins) expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.

  9. these findings indicate the importance of NHE3 in diabetic diarrhea and suggest LPA administration as a potential therapeutic strategy for management of diabetic diarrhea.

  10. Myosin VI (show MYO6 Proteins) mediates the movement of NHE3 to the microvillus in intestinal epithelial cells.

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) interaction partners

  1. We demonstrate that NHE3-799C is a common variant of NHE3 that is enriched in Asian populations; however its presence seems to have limited clinical significance in humans and is not associated with compromised function or abnormal transport regulation.

  2. This review focuses on novel findings of NHE3 in the intestine and the kidney as well as novel drug developments targeting NHE3. [review]

  3. NHE3 binds to NHERF (show SLC9A3R1 Proteins) proteins via both an internal Class II PBM and C-terminal Class I PBM, which interact. The former determines NHE3 stability in the PM, and the latter determines total expression and percent PM expression.

  4. Expression of NHE3 and DRA was reduced with high tacrolimus levels and impaired renal function after intestinal transplantation.

  5. Recessive mutations in NHE3, a downstream target of GC-C (show GUCY2C Proteins), caused congenital sodium diarrhea and implied primary basal NHE3 malfunction as a predisposition for inflammatory bowel disease in a subset of patients.

  6. CCH-mediated inhibition of NHE3 activity is not dependent on clathrin and involves lipid rafts and requires Cdc42 (show CDC42 Proteins).

  7. Inflammation-induced loss of PDZK1 (show PDZK1 Proteins) expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.

  8. Data demonstrate a role for Per1 (show PER1 Proteins) in the transcriptional regulation of NHE3 and SGLT1 (show SLC5A1 Proteins) in the kidney.

  9. Results demonstrate decreased transport activity in three SNPs of NHE3 and provide mechanistic insight into how these SNPs impact NHE3 function.

  10. these findings indicate the importance of NHE3 in diabetic diarrhea and suggest LPA administration as a potential therapeutic strategy for management of diabetic diarrhea.

Pig (Porcine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3) interaction partners

  1. We propose that ouabain can simultaneously regulate renal tubule basolateral Na(+)-K(+)-ATPase (show ATP1A1 Proteins) and apical NHE3, leading to inhibition of transepithelial Na(+) transport.

SLC9A3 Protein Profile

Protein Summary

displays Na+/H+ exchanger transport activity\; mediates sodium ion transport across the renal proximal tubule

Alternative names and synonyms associated with SLC9A3

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 (SLC9A3)
  • sodium/hydrogen exchanger 3 (nhe3) (AaeL_AAEL001503)
  • Sodium/hydrogen exchanger 3 (GL50803_102647)
  • sodium/hydrogen exchanger 3 (nhe3) (Smp_045680)
  • Na/H exchanger 3 (NHE-3)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 (Slc9a3)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 (Slc9a3)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 (SLC9A3)
  • 9030624O13Rik protein
  • AI930210 protein
  • NHE-3 protein
  • Nhe3 protein
  • SLC9A3 protein

Protein level used designations for SLC9A3

sodium proton exchanger , sodium/hydrogen exchanger 3 , solute carrier family 9 (sodium/hydrogen exchanger), member 3 , sodium/hydrogen exchanger 3 (nhe3) , Sodium/hydrogen exchanger 3 , Na(+)/H(+) exchanger 3 , Na+/H+ exchanger homolog , solute carrier family 9 member 3 , NHE-3 , Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive) , plasma membrane ion transport protein , solute carrier family 9, member 3 , solute carrier family 9 (sodium/hydrogen exchanger) , sodium/hydrogen exchanger

GENE ID SPECIES
407112 Bos taurus
420801 Gallus gallus
5570922 Aedes aegypti
5698518 Giardia lamblia ATCC 50803
8348267 Schistosoma mansoni
100009430 Oryctolagus cuniculus
105243 Mus musculus
24784 Rattus norvegicus
6550 Homo sapiens
397358 Sus scrofa
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