This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This DANRE hey2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the C-terminal region of DANRE hey2.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Winkler, Elmasri, Klamt, Volff, Gessler: "Characterization of hey bHLH genes in teleost fish." in: Development genes and evolution, Vol. 213, Issue 11, pp. 541-53, (2003) (PubMed).
Zhong, Childs, Leu, Fishman: "Gridlock signalling pathway fashions the first embryonic artery." in: Nature, Vol. 414, Issue 6860, pp. 216-20, (2001) (PubMed).
Zhong, Rosenberg, Mohideen, Weinstein, Fishman: "gridlock, an HLH gene required for assembly of the aorta in zebrafish." in: Science (New York, N.Y.), Vol. 287, Issue 5459, pp. 1820-4, (2000) (PubMed).
Target
HEY2
(Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2))
CHF1 antibody, GRIDLOCK antibody, GRL antibody, HERP1 antibody, HESR2 antibody, HRT2 antibody, bHLHb32 antibody, Herp1 antibody, Hrt2 antibody, hesr2 antibody, grl antibody, zgc:136746 antibody, hes related family bHLH transcription factor with YRPW motif 2 antibody, hairy/enhancer-of-split related with YRPW motif 2 antibody, hes-related family bHLH transcription factor with YRPW motif 2 antibody, HEY2 antibody, Hey2 antibody, hey2 antibody
Background
Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation.