This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SUPV3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human SUPV3L1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Szczesny, Borowski, Brzezniak, Dmochowska, Gewartowski, Bartnik, Stepien: "Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance." in: Nucleic acids research, Vol. 38, Issue 1, pp. 279-98, (2010) (PubMed).
Wang, Shu, Lieser, Chen, Lee: "Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality." in: The Journal of biological chemistry, Vol. 284, Issue 31, pp. 20812-21, (2009) (PubMed).
Khidr, Wu, Davila, Procaccio, Wallace, Lee: "Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 27064-73, (2008) (PubMed).
Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, (2008) (PubMed).
Pereira, Mason, Szczesny, Maddukuri, Dziwura, Jedrzejczak, Paul, Wojcik, Dybczynska, Tudek, Bartnik, Klysik, Bohr, Stepien: "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality." in: Mechanisms of ageing and development, Vol. 128, Issue 11-12, pp. 609-17, (2007) (PubMed).
SUV3 antibody, 6330443E10Rik antibody, wu:fc19b02 antibody, wu:fe37e06 antibody, Suv3 like RNA helicase antibody, suppressor of var1, 3-like 1 (S. cerevisiae) antibody, SUV3-like helicase antibody, SUPV3L1 antibody, Supv3l1 antibody, supv3l1 antibody
Background
SUV3L1 is an ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. It may protect cells from apoptosis.