This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This GRIN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the Central region of human GRIN2C.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Need, Keefe, Ge, Grossman, Dickson, McEvoy, Goldstein: "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis." in: European journal of human genetics : EJHG, Vol. 17, Issue 7, pp. 946-57, (2009) (PubMed).
Krapivinsky, Krapivinsky, Manasian, Ivanov, Tyzio, Pellegrino, Ben-Ari, Clapham, Medina: "The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1." in: Neuron, Vol. 40, Issue 4, pp. 775-84, (2003) (PubMed).
Self, Mulholland, Nath, Harris, Prendergast: "The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site." in: Brain research, Vol. 995, Issue 1, pp. 39-45, (2003) (PubMed).
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq].