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FAS antibody

FAS Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1944804
  • Target See all FAS Antibodies
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Reactivity
    • 213
    • 67
    • 62
    • 19
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 158
    • 89
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 155
    • 100
    • 1
    Polyclonal
    Conjugate
    • 123
    • 27
    • 25
    • 12
    • 10
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FAS antibody is un-conjugated
    Application
    • 164
    • 117
    • 74
    • 64
    • 36
    • 35
    • 31
    • 26
    • 26
    • 20
    • 19
    • 9
    • 8
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Isotype
    IgG1
    Top Product
    Discover our top product FAS Primary Antibody
  • Application Notes
    WB: 1:1000. IHC: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Storage
    4 °C,-20 °C
  • Cascino, Papoff, De Maria, Testi, Ruberti: "Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 1, pp. 13-7, (1996) (PubMed).

    Liu, Cheng, Mountz: "Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation." in: The Biochemical journal, Vol. 310 ( Pt 3), pp. 957-63, (1995) (PubMed).

    Cascino, Fiucci, Papoff, Ruberti: "Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 6, pp. 2706-13, (1995) (PubMed).

    Oehm, Behrmann, Falk, Pawlita, Maier, Klas, Li-Weber, Richards, Dhein, Trauth: "Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen." in: The Journal of biological chemistry, Vol. 267, Issue 15, pp. 10709-15, (1992) (PubMed).

  • Target
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Alternative Name
    FAS (FAS Products)
    Synonyms
    ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody
    Background
    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
    Molecular Weight
    37732 Da
    Gene ID
    355
    UniProt
    P25445
    Pathways
    p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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