IL1R2 antibody

Catalog No. ABIN2192180

Product Details anti-IL1R2 Antibody

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1R2 antibody is un-conjugated

Application: Immunoassay (IA)

Sterility: 0.2 μm filtered

Application Details

Application Notes: For immuno assays dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-IL1R2 antibody (ABIN2192180)

Mantovani, Muzio, Ghezzi, Colotta, Introna: "Regulation of inhibitory pathways of the interleukin-1 system." in: Annals of the New York Academy of Sciences, Vol. 840, pp. 338-51, (1998) (PubMed).

Target Details for IL1R2

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Abstract: IL1R2 Products

Synonyms: CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody

Background: The antibody reacts specificly with human Interleukin (IL-1) R II. The IL-1 system includes two agonists (IL- 1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signalling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.

Pathways: NF-kappaB Signaling