IL1R2 antibody (AA 20-320)

Catalog No. ABIN7156749

Product Details anti-IL1R2 Antibody

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Binding Specificity: AA 20-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1R2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Interleukin-1 receptor type 2 protein (20-320AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IL1R2

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Alternative Name: IL1R2 (IL1R2 Products)

Synonyms: CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody

Background:

Background: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Aliases: IL1 Receptor II antibody, Antigen CDw121b antibody, CD121 antibody, CD121 antigen-like family member B antibody, CD121b antibody, CD121B Antigen antibody, CDw121b antibody, IL 1 type II receptor antibody, IL-1R-2 antibody, IL-1R-beta antibody, IL-1R2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R Beta antibody, Il1r-2 antibody, IL1R2 antibody, IL1R2_HUMAN antibody, IL1R2c antibody, IL1RB antibody, Interleukin 1 receptor type II variant 3 antibody, Interleukin 1 receptor, beta, type II antibody, Interleukin 1 receptor, type II antibody, Interleukin-1 receptor beta antibody, Interleukin-1 receptor type 2 antibody, Interleukin-1 receptor type II antibody, MGC137383 antibody, MGC47725 antibody, OTTHUMP00000207969 antibody, p68 antibody, Type II interleukin-1 receptor, beta antibody

UniProt: P27930

Pathways: NF-kappaB Signaling