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The data demonstrate a novel and unexpected function of BIG1 (show CNTN3 ELISA Kits) that regulates TNFR1 (show TNFRSF1A ELISA Kits) signaling by targeting TRAF2 (show TRAF2 ELISA Kits).
Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of PKA-phosphorylated beta-catenin S675 and beta-catenin association with PKA, BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion.
Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
an early acting GEF (GBF1 (show GBF1 ELISA Kits)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (show CNTN3 ELISA Kits)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (show TG ELISA Kits) continuum.
BIG1 (show CNTN3 ELISA Kits), through its ability to activate ADP-ribosylation factor 1 (show ARF1 ELISA Kits), regulates cell-surface levels and function of ABCA1 (show ABCA1 ELISA Kits).
BIG1 and KANK1 play roles in regulating cell polarity during directed migration in wound healing.
Promoter methylations of CAMK2B (show CAMK2B ELISA Kits) and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
BIG1 (show CNTN3 ELISA Kits) binds to FKBP13 (show FKBP2 ELISA Kits), playing a role in vesicular trafficking
data are consistent with independent intracellular movements and actions of BIG1 (show CNTN3 ELISA Kits) and BIG2, and they are also evidence of the participation of BIG1 (show CNTN3 ELISA Kits) in both Golgi and nuclear functions
myosin IXb binds to BIG1, which regulates its Rho-GTPase activating protein activity
an early acting GEF (show ARHGEF2 ELISA Kits) (GBF1 (show PTGES2 ELISA Kits)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (show CNTN3 ELISA Kits)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (show TG ELISA Kits) continuum.
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
, brefeldin A-inhibited guanine nucleotide-exchange protein 1
, p200 ARF guanine nucleotide exchange factor
, brefeldin A-inhibited GEP 1
, p200 ARF-GEP1
, ADP-ribosylation factor guanine nucleotide-exchange factor 1