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Human Polyclonal NEPH1 Primary Antibody for WB - ABIN1881479
Sellin, Huber, Gerke, Quack, Pavenstädt, Walz: NEPH1 defines a novel family of podocin interacting proteins. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Show all 6 references for ABIN1881479
Human Polyclonal NEPH1 Primary Antibody for WB - ABIN2782952
Harita, Kurihara, Kosako, Tezuka, Sekine, Igarashi, Hattori: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. in The Journal of biological chemistry 2008
Show all 2 references for ABIN2782952
maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN (show SUPT6H Antibodies)-induced injury and PAN (show SUPT6H Antibodies)-induced albumin (show ALB Antibodies) leakage
Neph1-CD adopts a global shape in solution, and its interaction with ZO-1 (show TJP1 Antibodies) involves multiple sites.
Localization of Neph1 to the podocyte cell membrane is altered in the presence of mutant Myo1c (show MYO1C Antibodies), and is actin dependent. Knockdown of Myo1c (show MYO1C Antibodies) inhibits Neph1 membrane localization. Neph1 is critical for the maintenance of glomerular function.
A striking finding in this study is the lack of contribution of NEPH1, NPHS1, and NPHS2 genes in 15 Asian families with steroid-resistant nephrotic syndrome.
common variants in LRRC7 (show LRRC7 Antibodies), KIRREL, NPHS2 and ACTN4 (show ACTN4 Antibodies) do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
Neph1 but not nephrin (show NPHS1 Antibodies) specifically binds to adaptor protein Grb2 (show GRB2 Antibodies) and tyrosine kinase (show TXK Antibodies) Csk (show CSK Antibodies) in a phosphorylation-dependent manner.
Neph1-Nephrin (show NPHS1 Antibodies) proteins bind the Par3 (show F2RL2 Antibodies)-Par6 (show PARD6A Antibodies)-atypical protein kinase C (show PRKCZ Antibodies) (aPKC) complex to regulate podocyte cell polarity
tyrosine phosphorylation of Neph1 mediated by Fyn (show FYN Antibodies) results in significantly increased Neph1 and ZO-1 (show TJP1 Antibodies) binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 (show TJP1 Antibodies) complex.
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Fyn (show FYN Antibodies) catalyzes Nephrin (show NPHS1 Antibodies) phosphorylation in podocyte detergent-resistant membrane fractions.
nephrin (show NPHS1 Antibodies) and Neph1 interact and have roles in glomerular permeability
In the adult brain, Neph1 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph1 is seen in dendritic shafts of pyramidal neurons.
Nephrin-Neph1 complex transduces phosphorylation-mediated signals that assemble an actin polymerization complex at the podocyte intercellular junction.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2\; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003
, kin of IRRE-like protein 1
, kin of irregular chiasm-like protein 1
, nephrin-like protein 1
, kin of IRRE like 1
, nephrin 1