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RanBP9 (show RANBP9 Proteins)/TSSC3 complex cooperatively suppress metastasis via downregulation of Src (show SRC Proteins)-dependent Akt (show AKT1 Proteins) pathway to expedite mitochondrial-associated anoikis.
PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion.
TSSC3 was a prognostic marker in osteosarcoma.
TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta
Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.
PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts.
The gene expression pattern of CDKN1C (show CDKN1C Proteins), H19 (show NCKAP1 Proteins), IGF2, KCNQ1 (show KCNQ1 Proteins) and PHLDA2 genes was evaluated using RT-PCR.
results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction
TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 (show CASP3 Proteins) upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth
TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells
Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.
data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve
TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT (show AKT1 Proteins)/MASH2 (show ASCL2 Proteins) signaling pathway.
Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.
A critical role for the imprinted Phlda2 gene in regulating glycogen (show GYS1 Proteins) storage in the eutherian placenta is identified.
Embryonic expression of Ipl in mice
Ipl and Tih1 (show PHLDA3 Proteins) are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 Proteins).
In the present study, a 259 base pair-specific sequence for IPL gene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified in IPL exon 1. Variable imprinting status of this gene was observed in different developmental stages.
Quantitative allelic sequencing supports maternal expression of PHLDA2 in fetal liver and placental tissues using an interbreed swine model.
imprinting status of four cattle genes (Tssc4 (show TSSC4 Proteins),Nap1l4 (show NAP1L4 Proteins), Phlda2 and Osbpl5 (show OSBPL5 Proteins)) in seven types of tissues, were assessed in cattle.
proper expression levels of the imprinted genes CDKN1C (show CDKN1C Proteins) and PHLDA2 are critical for embryo development
Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.
This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
pleckstrin homology-like domain, family A, member 2
, pleckstrin homology-like domain family A member 2
, Imprinted in placenta and liver protein
, beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein
, imprinted in placenta and liver protein
, p17-Beckwith-Wiedemann region 1 C
, p17-Beckwith-Wiedemann region 1C
, tumor suppressing subchromosomal transferable fragment cDNA 3
, tumor suppressing subtransferable candidate 3
, tumor-suppressing STF cDNA 3 protein
, tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
, tumor-supressing STF cDNA 3
, protein 50C15
, tumor-suppressing subchromosomal transferable fragment 3