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Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch (show NOTCH1 Proteins) dependent.
PTH1R mutation is associated with Primary Failure of Tooth Eruption.
Data suggest that GCGR (glucagon receptor (show GCGR Proteins)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (show GCGR Proteins) or PTH1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
data highlight sequences in PTHR that contribute to NHERF1 (show SLC9A3R1 Proteins) interaction and can be altered to prevent phosphorylation-mediated inhibition
Overt hypercalcemia is not always encountered in Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutation.
data are consistent with the hypothesis that the pattern of C-terminal tail phosphorylation on PTH1R may determine the signaling outcome following receptor activation.
the data presented in this manuscript demonstrate a critical function of VPS35 (show vps35 Proteins) in regulating PTH1R trafficking. This event and VPS35 (show vps35 Proteins)-interaction with PPP1R14C (show PPP1R14C Proteins) appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling.
PTH1R mutation causing primary failure of tooth eruption in a consanguineous Saudi family.
A critical role for SNX27 (show SNX27 Proteins)-retromer mediated transport of PTHR in normal bone development.
PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway stimulates the expressions of RANKL (show TNFSF11 Proteins), PTHrP, and BMP-2 (show BMP2 Proteins) partly through NF-kappaB (show NFKB1 Proteins), suggesting its importance for bone metastasis of prostate carcinoma
CaSR (show CASR Proteins) and PTH1R signaling responses in cartilage and bone. [review]
Results provide in vivo evidence of a role for RAMP2 (show RAMP2 Proteins) in placental development distinct from the RAMP2 (show RAMP2 Proteins)-calcitonin receptor-like receptor (show CALCRL Proteins)/adrenomedullin (show ADM Proteins) signaling paradigm; decreases Pthr1 expression and causes a blunted response to systemic parathyroid hormone (show PTH Proteins); and identify additional pathways underlying the endocrine and fertility defects of the previously characterized Ramp2 (show RAMP2 Proteins) heterozygous adult females.
Activation of PTHrP-cyclic AMP (show TMPRSS5 Proteins)-CREB1 (show CREB1 Proteins) signaling following p53 (show TP53 Proteins) loss is essential for osteosarcoma initiation and maintenance.
PTHrP and PTH (show PTH Proteins) mediate wasting through a common mechanism involving PTHR.
we propose that PTH (show PTH Proteins) has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling
Ihh (show IHH Proteins) and PTH1R signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.
cells expressing osterix (show SP7 Proteins) are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.
PTH1R regulates systemic mineral ion homeostasis and induction of FGF23 (show FGF23 Proteins).
PTH1R is an important component of mechanical signal transduction in osteocytic MLO-Y4 cells.
These studies reveal that PTH1R signaling in osteoblasts regulates cartilaginous growth plate for postnatal growth of bone.
The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.
This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Proteins), FAF1 (show FAF1 Proteins) and PTH1R with some of leg weakness related traits in pigs.
These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.
PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.
parathyroid hormone receptor 1
, parathyroid hormone/parathyroid hormone-related peptide receptor
, parathyroid hormone 1 receptor
, PTH/PTHr receptor
, PTH/PTHrP type I receptor
, PTH1 receptor
, Parathyroid hormone/parathyroid hormone-related peptide receptor
, parathyroid hormone/parathyroid hormone-related peptide receptor-like
, parathyroid hormone/parathyroid hormone-related protein receptor
, seven transmembrane helix receptor
, PTH-related peptide receptor
, PTH/PTHrP receptor
, parathyroid hormone receptor-1
, parathyroid receptor