Browse our PTH1R Proteins (PTH1R)

Full name:
Parathyroid Hormone 1 Receptor Proteins (PTH1R)
On are 20 Parathyroid Hormone 1 Receptor (PTH1R) Proteins from 8 different suppliers available. Additionally we are shipping PTH1R Antibodies (79) and PTH1R Kits (11) and many more products for this protein. A total of 116 PTH1R products are currently listed.
PFE, PPR, PTH, PTH1, Pthr, Pthr1, PTHrel, zPTH1R
list all proteins Gene Name GeneID UniProt
PTH1R 5745 Q03431
PTH1R 19228 P41593
Rat PTH1R PTH1R 56813 P25961

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PTH1R Proteins (PTH1R) by Origin

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Top referenced PTH1R Proteins

  1. Human PTH1R Protein expressed in Human Cells - ABIN2005129 : Schipani, Karga, Karaplis, Potts, Kronenberg, Segre, Abou-Samra, Jüppner: Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. in Endocrinology 1993 (PubMed)
    Show all 4 references for 2005129

  2. Human PTH1R Protein expressed in HEK-293 Cells - ABIN2181675 : Johnston, Kimple, Giguère, Siderovski: Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. in Structure (London, England : 1993) 2008 (PubMed)
    Show all 3 references for 2181675

More Proteins for PTH1R Interaction Partners

Zebrafish Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. Loss of function of either PTHR1 or PTHrP in zebrafish leads to a localized aortic defect that is Notch (show NOTCH1 Proteins) dependent.

Human Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. PTH1R mutation is associated with Primary Failure of Tooth Eruption.

  2. Data suggest that GCGR (glucagon receptor (show GCGR Proteins)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (show GCGR Proteins) or PTH1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.

  3. data highlight sequences in PTHR that contribute to NHERF1 (show SLC9A3R1 Proteins) interaction and can be altered to prevent phosphorylation-mediated inhibition

  4. Overt hypercalcemia is not always encountered in Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutation.

  5. data are consistent with the hypothesis that the pattern of C-terminal tail phosphorylation on PTH1R may determine the signaling outcome following receptor activation.

  6. the data presented in this manuscript demonstrate a critical function of VPS35 (show vps35 Proteins) in regulating PTH1R trafficking. This event and VPS35 (show vps35 Proteins)-interaction with PPP1R14C (show PPP1R14C Proteins) appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling.

  7. PTH1R mutation causing primary failure of tooth eruption in a consanguineous Saudi family.

  8. A critical role for SNX27 (show SNX27 Proteins)-retromer mediated transport of PTHR in normal bone development.

  9. PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway stimulates the expressions of RANKL (show TNFSF11 Proteins), PTHrP, and BMP-2 (show BMP2 Proteins) partly through NF-kappaB (show NFKB1 Proteins), suggesting its importance for bone metastasis of prostate carcinoma

  10. CaSR (show CASR Proteins) and PTH1R signaling responses in cartilage and bone. [review]

Mouse (Murine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. Activation of PTHrP-cyclic AMP (show TMPRSS5 Proteins)-CREB1 (show CREB1 Proteins) signaling following p53 (show TP53 Proteins) loss is essential for osteosarcoma initiation and maintenance.

  2. A critical role for SNX27 (show SNX27 Proteins)-retromer mediated transport of PTHR in normal bone development.

  3. PTHrP and PTH (show PTH Proteins) mediate wasting through a common mechanism involving PTHR.

  4. we propose that PTH (show PTH Proteins) has a direct effect on osteoblasts and osteoclasts, and that this effect is mediated through PTH1R, thus contributing to bone remodeling

  5. Ihh (show IHH Proteins) and PTH1R signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.

  6. cells expressing osterix (show SP7 Proteins) are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.

  7. PTH1R regulates systemic mineral ion homeostasis and induction of FGF23 (show FGF23 Proteins).

  8. PTH1R is an important component of mechanical signal transduction in osteocytic MLO-Y4 cells.

  9. These studies reveal that PTH1R signaling in osteoblasts regulates cartilaginous growth plate for postnatal growth of bone.

  10. Cbfbeta (show CBFB Proteins) functions in upregulating Ihh (show IHH Proteins) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR expression to enhance chondrocyte differentiation.

Cow (Bovine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.

Pig (Porcine) Parathyroid Hormone 1 Receptor (PTH1R) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Proteins), FAF1 (show FAF1 Proteins) and PTH1R with some of leg weakness related traits in pigs.

  2. These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.

  3. PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs

PTH1R Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with PTH1R

  • parathyroid hormone 1 receptor a (pth1ra)
  • parathyroid hormone 1 receptor (PTH1R)
  • parathyroid hormone 1 receptor (Pth1r)
  • PFE protein
  • PPR protein
  • PTH protein
  • PTH1 protein
  • Pthr protein
  • Pthr1 protein
  • PTHrel protein
  • zPTH1R protein

Protein level used designations for PTH1R

parathyroid hormone receptor 1 , parathyroid hormone/parathyroid hormone-related peptide receptor , parathyroid hormone 1 receptor , PTH/PTHr receptor , PTH/PTHrP type I receptor , PTH1 receptor , Parathyroid hormone/parathyroid hormone-related peptide receptor , parathyroid hormone/parathyroid hormone-related peptide receptor-like , parathyroid hormone/parathyroid hormone-related protein receptor , seven transmembrane helix receptor , PTH-related peptide receptor , PTH/PTHrP receptor , parathyroid hormone receptor-1 , parathyroid receptor

30629 Danio rerio
420401 Gallus gallus
461008 Pan troglodytes
712147 Macaca mulatta
100054278 Equus caballus
100190839 Pongo abelii
100402780 Callithrix jacchus
5745 Homo sapiens
19228 Mus musculus
56813 Rattus norvegicus
507783 Bos taurus
403779 Canis lupus familiaris
397675 Sus scrofa
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