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anti-Mouse (Murine) Antibodies:
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Mouse (Murine) Polyclonal RAB11A Primary Antibody for ELISA, WB - ABIN249623
Gromov, Celis, Hansen, Tommerup, Gromova, Madsen: Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins. in FEBS letters 1998
Cow (Bovine) Polyclonal RAB11A Primary Antibody for IHC, WB - ABIN2789607
Cebrian, Croce, Guerrero, Blanchard, Mayorga: Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. in EMBO reports 2016
During neural tube formation Rab11-positive recycling endosomes distribute to the medial apical cell junctions in the neural plate. Polarization was under the control of planar cell polarity signalling, and was necessary for neural plate folding.
Rab11 and the associated motor protein (show MYO7A Antibodies) Myosin V (show MYO5A Antibodies) play essential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 trafficking to the cell surface.
Rab11 expression is required throughout the early embryo for proper left-right patterning.
A requirement for Rab11 in multiciliated cells(MCC (show MCC Antibodies)) development and support a two-step model, in which the initial polarization of MCC (show MCC Antibodies) precursors is critical for their integration into the superficial cell layer.
Pard3 (show PARD3 Antibodies) and Rab11a are necessary for lumen formation in the neural rod.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (show Rab5c Antibodies) (early endosomes), Rab11a (recycling endosomes), and Rab7 (show RAB7A Antibodies) (late endosomes) to study localization and dynamics during development.
The results suggest that Rab11 regulates anterograde transport from the TGN to the plasma membrane and strongly implicate SYP122, rather than SYP121.
Data suggest that membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V)
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the hIP, and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms
transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates.
The results from this analysis indicated that Rab11a, Rab11c(Rab25 (show RAB25 Antibodies)) and Rab14 (show RAB14 Antibodies) were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line.
The results suggest that progressive assembly of vRNA segments may be cell type dependent and that vRNA may be transported through the cytoplasm without Rab11A-containing recycling endosomes in the absence of intact microtubules.
Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation
In colorectal carcinoma, overexpression of Rab11 was found to promote collective cell migration through the increased distribution of E-cadherin (show CDH1 Antibodies), which enhanced cell-cell connections.
A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1 (show FOSB Antibodies)-dependent Golgi-plasma membrane trafficking.
Analysis reveals novel aspects of the PI4KIIIb-Rab11 complex, specifically conformational changes induced in the switch regions of activated Rab11.
Substituted V20 of Rab11A was found to interfere with proper localization of the water molecule, which mediated GTP (show AK3 Antibodies) hydrolysis, resulting in GTP (show AK3 Antibodies) being locked in an active form of Rab11A S20V.
The authors determined crystal structures of MyoVa (show MYO5A Antibodies)-globular tail domain bound either to the Spir-2 (show SPIRE2 Antibodies) motif or to Rab11 and show that a Spir-2 (show SPIRE2 Antibodies):MyoVa:Rab11 complex can form.
Rab11a inactivation in macrophages as a result of apoptotic cell binding initiates phagocytosis of apoptotic neutrophils via the modulation of ADAM17 (show ADAM17 Antibodies)-mediated CD36 (show CD36 Antibodies) cell surface expression
Rab8a (show RAB8A Antibodies) and Rab11a Are Dispensable for Rhodopsin (show RHO Antibodies) Transport in Mouse Photoreceptors
The up-regulation of Rab11, Rab7 (show RAB7A Antibodies), or RILP (show RILP Antibodies), but not its truncated form RILP (show RILP Antibodies)-C33 (show CD82 Antibodies), rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 (show RAB7A Antibodies) impaired LAMP2A trafficking.
Rab11a/Rab11 family-interacting protein 2 (show RAB11FIP2 Antibodies)-mediated VE-cadherin (show CDH5 Antibodies) recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.
Rab11a-knockdown cells displayed mislocalization of STX3 (show STX3 Antibodies) and the presentation of microvilli in the basolateral compartment
Results define Glut3 to be a rab11-dependent trafficking cargo and suggest that impaired Glut3 trafficking arising from rab11 dysfunction underlies the glucose hypometabolism observed in Huntington's disease
LMTK1 (show AATK Antibodies) negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion
Thus, Rab11a endosome controls intestinal host-microbial homeostasis at least partially via sorting Toll (show TLR4 Antibodies)-like receptors, including Tlr9 (show TLR9 Antibodies).
Rab11a promotes Porcine reproductive and respiratory syndrome virus (PRRSV) replication and associates with PRRSV replication sites.
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.
RAB11A, member RAS oncogene family
, ras-related protein Rab-11A
, Rab11 GTPase
, rab11A protein
, Rab11a, GTPase
, rab11A, RAB family GTPase
, RAB 11A, member oncogene family
, rab11 GTP-binding protein
, tubulovesicle-associated protein