Browse our anti-SMURF1 (SMURF1) Antibodies

Full name:
anti-SMAD Specific E3 Ubiquitin Protein Ligase 1 Antibodies (SMURF1)
On are 109 SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) Antibodies from 17 different suppliers available. Additionally we are shipping SMURF1 Proteins (5) and SMURF1 Kits (3) and many more products for this protein. A total of 127 SMURF1 products are currently listed.
4930431E10Rik, mKIAA1625, RGD1309707
list all antibodies Gene Name GeneID UniProt
SMURF1 57154 Q9HCE7
SMURF1 75788 Q9CUN6
SMURF1 690516  

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anti-Human SMURF1 Antibodies:

anti-Mouse (Murine) SMURF1 Antibodies:

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Top referenced anti-SMURF1 Antibodies

  1. Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388828 : Tajima, Goto, Yoshida, Shinomiya, Sekimoto, Yoneda, Miyazono, Imamura: Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. in The Journal of biological chemistry 2003 (PubMed)
    Show all 8 references for 388828

  2. Human Polyclonal SMURF1 Primary Antibody for EIA, IHC (p) - ABIN357469 : Suzuki, Murakami, Fukuchi, Shimanuki, Shikauchi, Imamura, Miyazono: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. in The Journal of biological chemistry 2002 (PubMed)
    Show all 6 references for 357469

  3. Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388829 : Ebisawa, Fukuchi, Murakami, Chiba, Tanaka, Imamura, Miyazono: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for 388829

  4. Human Monoclonal SMURF1 Primary Antibody for IF, WB - ABIN2838593 : Franke, Balschun, Sina, Ellinghaus, Häsler, Mayr, Albrecht, Wittig, Buchert, Nikolaus, Gieger, Wichmann, Sventoraityte, Kupcinskas, Onnie, Gazouli, Anagnou, Strachan, McArdle, Mathew, Rutgeerts, Vermeire, Vatn, , Krawczak, Rosenstiel, Karlsen, Schreiber: Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). in Nature genetics 2010 (PubMed)
    Show all 5 references for 2838593

  5. Human Polyclonal SMURF1 Primary Antibody for EIA, WB - ABIN954864 : Alarcón, Zaromytidou, Xi, Gao, Yu, Fujisawa, Barlas, Miller, Manova-Todorova, Macias, Sapkota, Pan, Massagué: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. in Cell 2009 (PubMed)
    Show all 4 references for 954864

  6. Human Monoclonal SMURF1 Primary Antibody for IF, IHC (p) - ABIN566098 : Murakami, Mathew, Huang, Farahani, Peng, Olson, Etlinger: Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. in Experimental biology and medicine (Maywood, N.J.) 2010 (PubMed)
    Show all 2 references for 566098

  7. Human Polyclonal SMURF1 Primary Antibody for ELISA, WB - ABIN185500 : Ozdamar, Bose, Barrios-Rodiles, Wang, Zhang, Wrana: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against SMURF1 Interaction Partners

Human SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. SMU (show MLXIP Antibodies)RF1 is increased in patients with pulmonary arterial hypertension

  2. Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (show WEE1 Antibodies); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (show WEE1 Antibodies) = wee 1 (show WEE1 Antibodies) homolog [S pombe] protein)

  3. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.

  4. results reveal the regulatory circuit between RUNX2 (show RUNX2 Antibodies) and SMURF1 controls RUNX2 (show RUNX2 Antibodies) expression and regulates odntoblastic differentiation in hDPSCs.

  5. EGF (show EGF Antibodies)/Smurf1 inhibits Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 Antibodies).

  6. a model that CD166 (show ALCAM Antibodies) regulates MCAM (show MCAM Antibodies) through a signaling flow from activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and c-Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling to the inhibition of potential MCAM (show MCAM Antibodies) ubiquitin E3 ligases, betaTrCP (show BTRC Antibodies) and Smurf1.

  7. SND1 (show SND1 Antibodies) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA Antibodies) ubiquitination and degradation.

  8. NF-kappaB (show NFKB1 Antibodies) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.

  9. Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.

  10. The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (show CD44 Antibodies)(high) expressing.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (show FERMT2 Antibodies) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions

  2. miR (show MLXIP Antibodies)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension

  3. Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.

  4. Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.

  5. Smurf1 mediates NGF (show NGFB Antibodies) signaling and ubiquitinates RhoA (show RHOA Antibodies) in growth cones, regulating the need for local translation and degradation.

  6. Smurf-mediated endocytosis of Patched1 (show PTCH1 Antibodies) is required in sonic hedgehog (show SHH Antibodies) signal reception

  7. Inhibition of rhBMP-2-induced ALP (show CCL21A Antibodies) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  8. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 Antibodies) negatively regulates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

  9. These results suggest that the JNK (show MAPK8 Antibodies)/AP-1 (show JUN Antibodies) and ERK (show EPHB2 Antibodies)/Runx2 (show RUNX2 Antibodies) signaling pathways mediate TNF-alpha (show TNF Antibodies)-dependent Smurf1 transcription.

  10. Smurf1 is a negative feedback regulator for IFN-gamma (show IFNG Antibodies) signaling by targeting STAT1 (show STAT1 Antibodies) for ubiquitination and proteasomal degradation.

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Data demonstrate that Smurf1 and Smurf2 (show SMURF2 Antibodies) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

  2. In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.

SMURF1 Antigen Profile

Antigen Summary

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SMURF1

  • SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (LOC100220332) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) antibody
  • SMAD specific E3 ubiquitin protein ligase 1 (Smurf1) antibody
  • 4930431E10Rik antibody
  • mKIAA1625 antibody
  • RGD1309707 antibody

Protein level used designations for SMURF1

Smad ubiquitination regulatory factor 1 , E3 ubiquitin-protein ligase SMURF1 , SMAD specific E3 ubiquitin protein ligase 1 , e3 ubiquitin-protein ligase SMURF1-like , E3 ubiquitin ligase SMURF1 , SMAD-specific E3 ubiquitin-protein ligase 1 , Smad-specific E3 ubiquitin ligase 1 , hSMURF1 , SMAD ubiquitination regulatory factor 1 , xSMURF1

416487 Gallus gallus
513902 Bos taurus
608821 Canis lupus familiaris
100063241 Equus caballus
472670 Pan troglodytes
718616 Macaca mulatta
100081555 Ornithorhynchus anatinus
100220332 Taeniopygia guttata
100456599 Pongo abelii
100465094 Ailuropoda melanoleuca
100540915 Meleagris gallopavo
100556808 Anolis carolinensis
57154 Homo sapiens
75788 Mus musculus
100621443 Sus scrofa
690516 Rattus norvegicus
398131 Xenopus laevis
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