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|Antigen||Integrin beta 3 (ITGB3) Antibodies|
|Epitope||AA 753-786, C-Term Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Integrin beta 3 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-Integrin beta 3 AntibodyTarget Details Integrin beta 3 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Integrin beta-3(ITGB3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.|
|Sequence||FAKFEEERAR AKWDTANNPL YKEATSTFTN ITYR|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Integrin beta-3(ITGB3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Protein Name: Integrin beta-3
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin beta 3 (753-786aa FAKFEEERARAKWDTANNPLYKEATSTFTNITYR), identical to the related mouse and rat sequences|
Target Details Integrin beta 3Product Details anti-Integrin beta 3 Antibody Application Details Handling Images back to top
|Alternative Name||ITGB3 (ITGB3 Antibody Abstract)|
ITGB3 (INTEGRIN, BETA-3), also called GP3A, GPIIIa, CD61, is a protein that in humans is encoded by the ITGB3 gene. It is a cluster of differentiation found on thrombocytes. This gene is mapped to 17q21.32. And the GP3A gene has 14 exons. The 3-prime exon is larger than 1,700 nucleotides and contains the 3-prime untranslated region. The ITGB3 complex belongs to the integrin class of cell adhesion molecule receptors that share a common heterodimeric structure with alpha and beta subunits. Additionally, the ITGB3 complex mediates platelet aggregation by acting as a receptor for fibrinogen. Although the ITGB3 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
Synonyms: BDPLT2 antibody|CD 61 antibody|CD61 antibody|CD61 antigen antibody|GP3A antibody|GPIIIa antibody|GT antibody|HPA 1 antibody|HPA 4 antibody|Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody|Integrin beta chain beta 3 antibody|Integrin beta-3 antibody|ITB3_HUMAN antibody|ITG B3 antibody|ITGB 3 antibody|ITGB3 antibody|NAIT antibody| Platelet fibrinogen receptor beta subunit antibody|Platelet glycoprotein IIIa antibody|platelet glycoprotein IIIa precursor antibody|Platelet membrane glycoprotein IIIa antibody|PTP antibody
|Pathways||Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex|
Application DetailsProduct Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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