Browse our phosphodiesterase 6A, CGMP-Specific, Rod, alpha Proteins (PDE6A)

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phosphodiesterase 6A, CGMP-Specific, Rod, alpha Proteins (PDE6A)
On www.antibodies-online.com are 4 phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) Proteins from 3 different suppliers available. Additionally we are shipping phosphodiesterase 6A, CGMP-Specific, Rod, alpha Antibodies (39) and many more products for this protein. A total of 48 phosphodiesterase 6A, CGMP-Specific, Rod, alpha products are currently listed.
Synonyms:
CGPR-A, nmf282, Pdea, RP43, si:bz1d10.3, si:rp71-1d10.3
list all proteins Gene Name GeneID UniProt
PDE6A 5145 P16499
PDE6A 225600  
PDE6A 307401  

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More Proteins for phosphodiesterase 6A, CGMP-Specific, Rod, alpha Interaction Partners

Zebrafish phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

Cow (Bovine) phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

Human phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

  1. this is the first phenotypic description of arRP due to homozygous IVS6+1G>A mutations in PDE6A and these seem here to be associated with severe RP leading to early extinction of rod responses as well as reduced macular function.

  2. report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal (show CARD8 Proteins) symptoms of autosomal recessive retinitis pigmentosa

  3. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 (show PDE5A Proteins) and PDE6

  4. the p.Val685Met mutation in PDE6A causes retinal degeneration in humans

  5. Rod phosphodiesterase-6 PDE6A and PDE6B (show PDE6B Proteins) subunits are enzymatically equivalent.

  6. full transcriptional activity of the PDE6A gene requires both Nrl (show NRL Proteins) and Crx (show CRX Proteins)

Mouse (Murine) phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) interaction partners

  1. Study confirms the severity of different Pde6a mutations and indicates that compound heterozygous mutants behave like intermediates of the respective homozygous situations homologous to a case of human retinitis pigmentosa.

  2. A new mutation in Pde6a was identifies in a mouse model of retinal degeneration.

  3. cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin (show GNAT1 Proteins), through Wnt5a (show WNT5A Proteins)-Frizzled-2 (show FZD2 Proteins) cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization.

  4. AIPL1 (show AIPL1 Proteins) interacts with the catalytic subunit (alpha) of PDE6 and is needed for the assembly of functional rod PDE6 subunits.

  5. full transcriptional activity of the PDE6A gene requires both Nrl (show NRL Proteins) and Crx (show CRX Proteins)

  6. missense mutations were found in the catalytic domain of the Pde6a gene in two mouse models from an ethyl nitrosourea chemical mutagenesis screen.

phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A) Protein Profile

Protein Summary

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Alternative names and synonyms associated with phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A)

  • phosphodiesterase 6A, cGMP-specific, rod, alpha (pde6a)
  • phosphodiesterase 6A, cGMP-specific, rod, alpha (PDE6A)
  • phosphodiesterase 6A, cGMP-specific, rod, alpha (Pde6a)
  • CGPR-A protein
  • nmf282 protein
  • Pdea protein
  • RP43 protein
  • si:bz1d10.3 protein
  • si:rp71-1d10.3 protein

Protein level used designations for PDE6A

cGMP-specific , rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha , phosphodiesterase 6A, alpha subunit , phosphodiesterase 6A, cGMP-specific, rod, alpha , phosphodiesterase 6A-like , rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha-like , GMP-PDE alpha , PDE V-B1 , phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide , cGMP phosphodiesterase alpha subunit , rod photoreceptor cGMP phosphodiesterase alpha subunit , cGMP phosphodiesterase alpha , cGMP-phosphodiesterase alpha-subunit

GENE ID SPECIES
368410 Danio rerio
462184 Pan troglodytes
677688 Macaca mulatta
100028818 Monodelphis domestica
100342363 Oryctolagus cuniculus
100432609 Pongo abelii
100489913 Xenopus (Silurana) tropicalis
100596985 Nomascus leucogenys
281973 Bos taurus
101122024 Ovis aries
5145 Homo sapiens
225600 Mus musculus
307401 Rattus norvegicus
403620 Canis lupus familiaris
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