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Human BMP6 Protein expressed in Escherichia coli (E. coli) - ABIN413092
Jukes, Both, Leusink, Sterk, van Blitterswijk, de Boer: Endochondral bone tissue engineering using embryonic stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
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both bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins)) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (show BMPR1A Proteins)) and ALK2 (show ACRV1 Proteins), play crucial and distinct roles in this process.
Plasma BMP6 was significantly increased in chronic heart failure patients.
Our results independently add further evidence to the role of BMP6 mutations as likely contributing factors to late-onset moderate IO unrelated to mutations in the established five HH genes.
Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6, ALK2 (show ACRV1 Proteins) and BMPRII (show BMPR2 Proteins) had deeper growth than tumors with only BMP6 expression
study shows that patients with CRA (show MTMR11 Proteins) had high expression of BMP6 and hepcidin (show HAMP Proteins) and low expression of s-HJV (show HFE2 Proteins). BMP6 was found to be negatively correlated with s-HJV (show HFE2 Proteins); both regulate hepcidin (show HAMP Proteins) expression and play important roles in the development of anemia.
the combined delivery of VEGF (show VEGFA Proteins) and BMP-6 to the bone defect significantly enhanced bone repair through the enhancement of angiogenesis and the differentiation of endogenously recruited MSCs into the bone repair site.
BMP-6 upregulates somatostatin receptor actions, leading to reduction of GnRH-induced secretion of luteinizing hormone.
These observations suggest a novel role of BMP-6 in the inhibition of breast cancer metastasis by regulating secretion of MMPs(MMP-1 (show MMP1 Proteins)) in the tumor microenvironment.
BMP-dependent physical interaction of VE-cadherin (show CDH5 Proteins) with the BMP receptor (show BMPR1A Proteins) ALK2 (show ACRV1 Proteins) (BMPRI) and BMPRII (show BMPR2 Proteins), resulting in stabilization of the BMP receptor (show BMPR1A Proteins) complex and, thereby, the support of BMP6-Smad (show SMAD1 Proteins) signaling.
BMP6 and oxidized low-density lipoprotein independently and synergistically induced osteogenic differentiation and mineralization in vascular endothelial cells.
Report temporal regulation of BMP6 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
These data suggest that, in Hjv (show HFE2 Proteins)(-/-) females, Bmp6 can provide a signal adequate to maintain hepcidin (show HAMP Proteins) to a level sufficient to avoid extrahepatic iron loading.
The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin (show HFE2 Proteins) to regulate hepcidin (show HAMP Proteins) transcription and maintain systemic iron homeostasis.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 and lower CTGF (show CTGF Proteins) expression.
Western blot analysis demonstrated that following BMP2 (show BMP2 Proteins) and BMP7 (show BMP7 Proteins) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Proteins), BMP4 (show BMP4 Proteins), BMP6, BMP7 (show BMP7 Proteins), BMP9 (show GDF2 Proteins) and Wnt3a (show WNT3A Proteins) were increased compared with control cells
In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis (show HFE Proteins) and bone loss.
BMP6 expression levels may have potential as predictive markers for the progression of non-alcoholic liver disease.
The expression of BMP6 in periodontal ligaments may contribute to interaction between the tooth and bone during the eruption and anchoring process.
BMP-6 secreted by prostate cancer cells induces IL-6 (show IL6 Proteins) expression in macrophages; IL-6 (show IL6 Proteins), in turn, stimulates the neuroendocrine differentiation of prostate cancer cells.
these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.
These results are consistent with novel mechanisms for regulating Bmp6 and Hamp1 (show HAMP Proteins) expression.
High BMP6 expression is associated with cystic ovarian disease.
BMP-6 mRNA is increased during transition from primordial to primary/secondary follicles in the goat ovaries.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
bone morphogenetic protein 6
, VG-1-related protein
, Vg1-related sequence
, vegetal related growth factor (TGFB-related)
, vegetal-related (TGFB related) cytokine
, bone morphogenic protein 6