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Human BMP6 Protein expressed in HEK-293 - ABIN2666466
Andriopoulos, Corradini, Xia, Faasse, Chen, Grgurevic, Knutson, Pietrangelo, Vukicevic, Lin, Babitt: BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. in Nature genetics 2009
Show all 6 references for ABIN2666466
Human BMP6 Protein expressed in Escherichia coli (E. coli) - ABIN413092
Jukes, Both, Leusink, Sterk, van Blitterswijk, de Boer: Endochondral bone tissue engineering using embryonic stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 references for ABIN413092
study shows that patients with CRA (show MTMR11 Proteins) had high expression of BMP6 and hepcidin (show HAMP Proteins) and low expression of s-HJV (show HFE2 Proteins). BMP6 was found to be negatively correlated with s-HJV (show HFE2 Proteins); both regulate hepcidin (show HAMP Proteins) expression and play important roles in the development of anemia.
the combined delivery of VEGF (show VEGFA Proteins) and BMP-6 to the bone defect significantly enhanced bone repair through the enhancement of angiogenesis and the differentiation of endogenously recruited MSCs into the bone repair site.
BMP-6 upregulates somatostatin receptor actions, leading to reduction of GnRH-induced secretion of luteinizing hormone.
These observations suggest a novel role of BMP-6 in the inhibition of breast cancer metastasis by regulating secretion of MMPs(MMP-1 (show MMP1 Proteins)) in the tumor microenvironment.
BMP-dependent physical interaction of VE-cadherin (show CDH5 Proteins) with the BMP receptor (show BMPR1A Proteins) ALK2 (show ACRV1 Proteins) (BMPRI) and BMPRII (show BMPR2 Proteins), resulting in stabilization of the BMP receptor (show BMPR1A Proteins) complex and, thereby, the support of BMP6-Smad (show SMAD1 Proteins) signaling.
BMP6 and oxidized low-density lipoprotein independently and synergistically induced osteogenic differentiation and mineralization in vascular endothelial cells.
Identify 3 heterozygous missense mutations in BMP6 in patients with unexplained iron overload. These mutations lead to loss of signaling to SMAD (show SMAD1 Proteins) proteins and reduced hepcidin (show HAMP Proteins) production.
These results demonstrated that Hcy up-regulated hepcidin (show HAMP Proteins) expression through the BMP6/SMAD (show SMAD1 Proteins) pathway, suggesting a novel mechanism underlying the hyperhomocysteinemia-associated perturbation of iron homeostasis.
demonstrate that BMP6 is associated with radiographic severity in AS, supporting the role wingless-type like/BMP pathway on radiographic progression in AS
These observations imply that crosstalk between the VEGF (show VEGFA Proteins) and BMP-6 signaling pathways enhances osteogenic differentiation of MSCs.
Report temporal regulation of BMP6 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis (show HFE Proteins) and bone loss.
BMP6 expression levels may have potential as predictive markers for the progression of non-alcoholic liver disease.
The expression of BMP6 in periodontal ligaments may contribute to interaction between the tooth and bone during the eruption and anchoring process.
BMP-6 secreted by prostate cancer cells induces IL-6 (show IL6 Proteins) expression in macrophages; IL-6 (show IL6 Proteins), in turn, stimulates the neuroendocrine differentiation of prostate cancer cells.
these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.
These results are consistent with novel mechanisms for regulating Bmp6 and Hamp1 (show HAMP Proteins) expression.
Prostate cancer-derived BMP-6 stimulates tumor-associated macrophages to produce IL-1a (show IL1A Proteins) through a crosstalk between Smad1 (show SMAD1 Proteins) and NF-kB1 (show NFKB1 Proteins); IL-1a (show IL1A Proteins), in turn, promotes angiogenesis and prostate cancer growth.
In addition to identifying BMP-6 expression in association with xerostomia and xerophthalmia in primary SS, results suggest that BMP-6-induced exocrine dysfunction in SS is independent of autoantibodies and immune activation associated with the disease.
BMP-6 maintains epithelial polarity via intracellular signaling from basolaterally localized BMP receptors.
During ovulation induction BMP-6 plays an important role in improvement of oocyte quality and ovarian response of the aged female, possibly by regulation of ovarian inhibitor of DNA-binding proteins (Ids) and VEGF expression.
BMP-6 mRNA is increased during transition from primordial to primary/secondary follicles in the goat ovaries.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
bone morphogenetic protein 6
, VG-1-related protein
, Vg1-related sequence
, vegetal related growth factor (TGFB-related)
, vegetal-related (TGFB related) cytokine
, bone morphogenic protein 6