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Human FCGR1 Protein expressed in Human Cells - ABIN2002442
Barnes, Gavin, Tan, Mottram, Koentgen, Hogarth: FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. in Immunity 2002
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FcgammaRI (show FCGR1A Proteins)/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP (show ITPA Proteins)) than in the Treg-deficient non-ITP (show ITPA Proteins) and control mice
The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRI (show FCGR1A Proteins).
Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics.
This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS (show GNB5 Proteins).
N-glycans in FcgammaRIa (show FCGR1A Proteins) interact with the OmpA of E. coli K1 for inducing disease pathogenesis
observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcgammaRs, with FcgammaRI (show FCGR1A Proteins) mediating most of the signaling.
Inhibition of GCH1 (show GCH1 Proteins) prevented the Escherichia coli K1 induced expression of CD64 (show FCGR1A Proteins) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.
The PI3K inhibitor LY294002 inhibited BCR (show BCR Proteins)-mediated, but not TLR-mediated, induction of IkappaB-zeta (show NFKBIZ Proteins), consistent with the role of PI3K in BCR (show BCR Proteins) signaling and its suppression by FcgammaR.
Dap12 (show TYROBP Proteins)- and FcRgamma (show FCER1G Proteins)-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor (show CSF2 Proteins)-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells.
Tpl2 (show MAP3K8 Proteins) is activated by FcgammaR signals in macrophages and that its activation by these signals is required for ERK (show EPHB2 Proteins) activation, cytoplasmic Ca(2 (show CA2 Proteins)+) influx, the induction of cytokine and coreceptor gene expression, and phagocytosis.
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
IgG high affinity Fc receptor
, fc-gamma RI
, high affinity immunoglobulin gamma Fc receptor I
, igG Fc receptor I