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Browse our PVRL2 Proteins (PVRL2)

Full name:
Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) Proteins (PVRL2)
On are 28 Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) Proteins from 9 different suppliers available. Additionally we are shipping PVRL2 Antibodies (131) and PVRL2 Kits (6) and many more products for this protein. A total of 179 PVRL2 products are currently listed.
AI325026, AI987993, CD112, HVEB, MPH, nectin-2, PRR2, Pvr, PVRR2, Pvs
list all proteins Gene Name GeneID UniProt
PVRL2 19294 P32507
PVRL2 308417  
PVRL2 5819 Q92692

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PVRL2 Proteins (PVRL2) by Origin

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Top referenced PVRL2 Proteins

  1. Human PVRL2 Protein expressed in Human Cells - ABIN2001864 : Lopez, Aoubala, Jordier, Isnardon, Gomez, Dubreuil: The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule. in Blood 1999 (PubMed)
    Show all 4 references for ABIN2001864

  2. Rat (Rattus) PVRL2 Protein expressed in Human Cells - ABIN2009494 : Peng, Mandai, Nakanishi, Ikeda, Asada, Momose, Shibamoto, Yanagihara, Shiozaki, Monden, Takeichi, Takai: Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line. in Oncogene 2002 (PubMed)
    Show all 4 references for ABIN2009494

  3. Mouse (Murine) PVRL2 Protein expressed in Human Cells - ABIN2007658 : Cocchi, Menotti, Dubreuil, Lopez, Campadelli-Fiume et al.: Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and ... in Journal of virology 2000 (PubMed)
    Show all 4 references for ABIN2007658

More Proteins for PVRL2 Interaction Partners

Mouse (Murine) Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) interaction partners

  1. Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 (show PVR Proteins) deficiency in immune surveillance against methylcholanthrene-induced tumors.

  2. We showed that cadherin and nectin (show PVRL1 Proteins) in the junctions of A431 cells and human keratinocytes are located in separate clusters.

  3. nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis

  4. Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion

  5. nectins and afadin are involved in dynamic epithelial remodeling during mouse development

  6. Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB (show CREB1 Proteins), c-Jun (show JUN Proteins), and Sp1 (show SP1 Proteins) family protein.

  7. Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed.

  8. Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction.

Human Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) interaction partners

  1. Serum levels of nectin-2 may have diagnostic roles for colorectal cancer patients.

  2. Soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.

  3. PVRL2, TOMM40 (show TOMM40 Proteins) and APOE (show APOE Proteins) might be associated with human longevity.

  4. Nectin-3 (show PVRL3 Proteins) trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation.

  5. Chorionic gonadotropin induces vascular endothelial growth factor (VEGFA (show VEGFA Proteins))-dependent downregulation of nectin 2, which increases the endothelial permeability in the coculture system.

  6. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.

  7. Data show that a high expression of CD112 and CD155 (show PVR Proteins) (DNAM-1 (show CD226 Proteins) ligands) on leukemic blasts.

  8. a possible etiologic role of PRR2 in nonsyndromic cleft lip with or without cleft palate

  9. The CD112 is highly expressed in colon carcinoma tissues and cell lines.

  10. The authors now show that human cytomegalovirus targets CD112 for proteasome-mediated degradation by 48 h post-infection, thus removing both activating ligands for DNAM-1 (show CD226 Proteins) from the cell surface during productive infection.

PVRL2 Protein Profile

Protein Summary

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with PVRL2

  • poliovirus receptor-related 2 (herpesvirus entry mediator B) (Pvrl2)
  • poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2)
  • poliovirus receptor-related 2 (Pvrl2)
  • AI325026 protein
  • AI987993 protein
  • CD112 protein
  • HVEB protein
  • MPH protein
  • nectin-2 protein
  • PRR2 protein
  • Pvr protein
  • PVRR2 protein
  • Pvs protein

Protein level used designations for PVRL2

poliovirus receptor-related protein 2 , herpes virus entry mediator B , herpesvirus entry mediator B , hveB , mHveB , murine herpes virus entry protein B , murine herpesvirus entry protein B , poliovirus receptor homolog , poliovirus sensitivity , nectin-2 , poliovirus receptor related 2 , poliovirus receptor-related 2 (herpesvirus entry mediator B) , herpesvirus entry protein B , poliovirus receptor-like 2

100730603 Cavia porcellus
611060 Canis lupus familiaris
505580 Bos taurus
19294 Mus musculus
308417 Rattus norvegicus
5819 Homo sapiens
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