Browse our ANGPTL4 Proteins (ANGPTL4)

Full name:
Angiopoietin-Like 4 Proteins (ANGPTL4)
On are 42 Angiopoietin-Like 4 (ANGPTL4) Proteins from 12 different suppliers available. Additionally we are shipping ANGPTL4 Antibodies (154) and ANGPTL4 Kits (60) and many more products for this protein. A total of 270 ANGPTL4 products are currently listed.
ANGPTL2, ANGPTL4, ARP4, Bk89, fiaf, HFARP, im:7144703, Ng27, NL2, PGAR, Pgarg, pp1158, si:rp71-39b20.7
list all proteins Gene Name GeneID UniProt
ANGPTL4 57875 Q9Z1P8
ANGPTL4 51129 Q9BY76
ANGPTL4 362850 Q6TMA8

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ANGPTL4 Proteins (ANGPTL4) by Origin

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Top referenced ANGPTL4 Proteins

  1. Human ANGPTL4 Protein expressed in HEK-293 Cells - ABIN2180590 : Nam, Yoon, Park: A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. in Journal of biomedical materials research 2000 (PubMed)
    Show all 4 references for 2180590

  2. Human ANGPTL4 Protein expressed in Wheat germ - ABIN1345057 : Basak, Duttaroy: cis-9,trans-11 conjugated linoleic acid stimulates expression of angiopoietin like-4 in the placental extravillous trophoblast cells. in Biochimica et biophysica acta 2013 (PubMed)
    Show all 2 references for 1345057

More Proteins for ANGPTL4 Interaction Partners

Cow (Bovine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow

  2. These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.

Mouse (Murine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL (show LPL Proteins) in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL (show LPL Proteins) by stimulating LPL (show LPL Proteins) degradation after LPL (show LPL Proteins) processing in the endoplasmic reticulum (ER).

  2. This study shows that TNF-alpha (show TNF Proteins), by a Foxo1 (show FOXO1 Proteins) dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL (show LPL Proteins).

  3. Angptl4-deficient mice show impaired insulin (show INS Proteins) secretion and dysmorphic pancreatic islets.

  4. Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin (show INS Proteins) resistance, in addition to causing the downregulation of various insulin (show INS Proteins) signaling pathway-associated genes.

  5. ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to brown adipose tissue during cold.

  6. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 (show ANGPTL3 Proteins) and Angptl4 at different nutritional statuses.

  7. These results reveal that FTO (show FTO Proteins) regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4.

  8. these results suggest that IL-1beta (show IL1B Proteins) increases Angptl4 expression through a mechanism dependent on the JNK (show MAPK8 Proteins)-MAPK (show MAPK1 Proteins) signaling pathway in MC3T3-E1 cells.

  9. glucagon receptor (show GCGR Proteins) antagonist improves glycemia in diet-induced obese angptl4 knockout mice without increasing glucagon (show GCG Proteins) levels or alpha-cell proliferation, underscoring the importance of this protein.

  10. Angptl4 may play a role in osteoblastic differentiation, and possibly angiogenesis via regulation of VEGF

Human Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. enhanced expression of angiopoietin-like 4 in rheumatoid arthritis may explain the occurrence of insulin (show INS Proteins) resistance, cardiovascular risk, and joint destruction [review]

  2. Neither serum nor urine Angptl4 appear to be good biomarkers in minimal change disease. Elevated urinary Angptl4 in glomerular disease appears to reflect the degree of proteinuria rather than any specific disease.

  3. results reveal that liganded GR spatiotemporally controls ANGPTL4 transcription in a chromosomal context.

  4. analyzed samples from our previously published studies on ANGPL4 levels in patients on hemodialysis and patients with diabetes type 2. These samples did not show false positive reactions. The levels of ANGPTL4 were comparable to those detected previously

  5. Oleic acid enhances head and neck squamous cell carcinoma metastasis through the ANGPTL4/fibronectin (show FN1 Proteins)/Rac1/Cdc42 (show CDC42 Proteins) and ANGPTL4/fibronectin (show FN1 Proteins)/MMP-9 (show MMP9 Proteins) signaling axes.

  6. Cyclic stretching of tendon fibroblasts stimulated the expression and release of ANGPTL4 protein.

  7. ANGPTL4 is secreted by human forearm muscle in postprandial conditions after a high-saturated fatty acid meal. Plasma ANGPTL4 concentrations were not associated with in vivo skeletal muscle LPL (show LCP1 Proteins) activity after a high-saturated fatty acid meal. Dietary fat quality affects plasma ANGPTL4, but it remains to be elucidated whether this influences short-term skeletal muscle lipid handling.

  8. angiopoietin-like 4 plays an important role in the regulation of epidermal growth factor (show EGF Proteins) induced cancer metastasis

  9. our data shows that ANGPTL3 (show ANGPTL3 Proteins), 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 (show ANGPTL3 Proteins) in the non-diabetic subjects while it associated more with ANGPTL4 in the obese and T2D subjects.

  10. Beyond rare-variant genetic association study determined rare hypertriglyceridemia causal ANGPTL4 variants based on high throughput sequencing.

Pig (Porcine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat

Zebrafish Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.

ANGPTL4 Protein Profile

Protein Summary

This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.

Alternative names and synonyms associated with ANGPTL4

  • angiopoietin-like 4 (ANGPTL4)
  • Angiopoietin-related protein 4 (angl4)
  • angiopoietin 4 (ANGPT4)
  • angiopoietin-like 4 (Angptl4)
  • angiopoietin-like 4 (angptl4)
  • ANGPTL2 protein
  • ANGPTL4 protein
  • ARP4 protein
  • Bk89 protein
  • fiaf protein
  • HFARP protein
  • im:7144703 protein
  • Ng27 protein
  • NL2 protein
  • PGAR protein
  • Pgarg protein
  • pp1158 protein
  • si:rp71-39b20.7 protein

Protein level used designations for Angiopoietin-Like 4 Proteins (ANGPTL4)

angiopoietin-like 4 , Angiopoietin-related protein 4 , angiopoietin-related protein 4-like , ANG-4 , angiopoietin-4 , angiopoietin-like protein 4 , 425O18-1 , angiopoietin-related protein 4 , fasting-induced adipose factor , fibrinogen/angiopoietin-related protein , hepatic fibrinogen/angiopoietin-related protein , major histocompatibility complex region NG27 , secreted protein Bk89 , PPARG angiopoietin related protein , hepatic angiopoietin-related protein , peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein , HFARP , PPARG angiopoietin-related protein , angiopoietin-like secreted glycoprotein 4 , angiopoietin-like 4 protein

476724 Canis lupus familiaris
743667 Pan troglodytes
769087 Gallus gallus
100194912 Salmo salar
100415086 Callithrix jacchus
100438448 Pongo abelii
617915 Bos taurus
57875 Mus musculus
51129 Homo sapiens
362850 Rattus norvegicus
397628 Sus scrofa
509963 Bos taurus
100860916 Capra hircus
492647 Danio rerio
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