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Human PNMT Protein expressed in Escherichia coli (E. coli) - ABIN666907
Ji, Salavaggione, Wang, Adjei, Eckloff, Wieben, Weinshilboum: Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. in Journal of neurochemistry 2005
Show all 2 references for ABIN666907
Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element.
PNMT gene is located within human chromosome 17q12 amplicon, including PPP1R1B (show PPP1R1B Proteins), STARD3 (show STARD3 Proteins), TCAP (show TCAP Proteins), PNMT, ERBB2 (show ERBB2 Proteins), MGC14832 and GRB7 (show GRB7 Proteins) genes. PPP1R1B (show PPP1R1B Proteins) ~ ERBB2 (show ERBB2 Proteins) ~ GRB7 (show GRB7 Proteins) locus is amplified in human gastric cancer and breast cancer.
initial velocity studies on human PNMT in the absence and presence of product and dead end (show DND1 Proteins) inhibitors.
The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese.
PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population.
In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality.
PNMT variants in cis (show CISH Proteins) may interact with nuclear factors in trans to govern adrenergic activity.
Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A.
Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis.
homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment
genetic variants of PNMT may play a role in the development of essential hypertension.
Presence of local PNMT transcription in human heart after transplantation.
Data suggest that Pnmt plays role in fear response and startle reactivity; compared with wild-type mice, Pnmt-knockout mice exhibit reduced contextual fear but normal cued fear.
Although temperature was normal in Pnmt(-/-) mice, the brown fat response to cold was abnormal with no increase in Ucp-1 or Pgc-1alpha mRNA levels (but with an exaggerated cold-induced lipid loss from the tissue).
surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice.
A truncated mouse phenylethanolamine N-methyltransferase splice variant has dominant-negative activity
PNMT expression is regulated late in mouse gestation by AP2-alpha (show TFAP2A Proteins) and glucocorticoids
clear, significant increase in aggression arising from PNMT overexpression
Regulation of the PNMT gene expression in various compartments of heart includes both corticosterone-dependent and independent mechanisms.
Transcriptional suppression by cAMP as a mechanism for regulating PNMT expression in both normal and neoplastic mouse chromaffin cells.
Neuronal nitric oxide synthase (show NOS1 Proteins) gene inactivation reduces the expression of vasopressin (show AVP Proteins) in the hypothalamic paraventricular nucleus and of PNMT in the adrenal gland of the mouse.
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.
, noradrenaline N-methyltransferase
, phenylethanolamine N-methylase