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Dog (Canine) Monoclonal CLNS1A Primary Antibody for WB - ABIN968447
Krapivinsky, Pu, Wickman, Krapivinsky, Clapham: pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. in The Journal of biological chemistry 1998
Show all 3 Pubmed References
the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo
functional interaction between ICln and HSPC038
RioK1 (show RIOK1 Antibodies), a new interactor of protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Antibodies)), competes with pICln for binding and modulates PRMT5 (show PRMT5 Antibodies) complex composition and substrate specificity.
revealed an increase of ICln in the mesothelioma cell membrane under hypotonic conditions, an event possibly related to the activation of Cl(-) channels
ICln interacts with integrin alphaIIbbeta3 and regulates platelet activation.
Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin (show PLEK Antibodies) homology (PH) domain family of proteins and interacts with LSm4 (show LSM4 Antibodies), a protein involved in splicing and mRNA degradation.
Lsm10 (show LSM10 Antibodies) and Lsm11 (show LSM11 Antibodies), which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 (show PRMT5 Antibodies) and SMN (show STMN1 Antibodies) complexes
ICln associates with the cell membrane after cell swelling
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
methylosome subunit pICln
, chloride channel, nucleotide-sensitive, 1A
, chloride channel regulatory protein
, chloride channel, nucleotide sensitive 1A
, chloride conductance regulatory protein ICln
, chloride ion current inducer protein
, reticulocyte pICln
, reticulocyte protein ICln
, chloride channel current inducer
, chloride channel regulator
, Clns 1a
, swelling-induced chloride conductance regulatory protein