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DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS (show RAP1GDS1 Proteins) and inhibiting the binding of other small GTPases to SmgGDS (show RAP1GDS1 Proteins)
we provide novel insights into the heterogeneous genomic landscape of relapsing chronic lymphocytic leukemia and report recurrent mutations in a "hotspot" region of RPS15
Study shows that ribosomal protein s15 (show RPS15 Proteins) is a key pathogenic LRRK2 (show LRRK2 Proteins) substrate in Drosophila and human neuron Parkinson's disease models.
RPL37 (show RPL37 Proteins), RPS15 (show RPS15 Proteins) and RPS20 (show RPS20 Proteins) regulate the Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-MdmX (show MDM4 Proteins) network but employ different mechanisms to do so.
DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis.
a novel Ras-related protein (show RASD1 Proteins) and potential neural tumor suppressor (RIG)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
DIRAS family, GTP-binding RAS-like 1
, GTP-binding protein Di-Ras1
, small GTP-binding tumor suppressor 1
, distinct subgroup of the Ras family member 1
, ras-related inhibitor of cell growth
, 40S ribosomal protein S15
, homolog of rat insulinoma
, insulinoma protein