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High eIF3c expression is positively associated with KRAS.
These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival.
eIF3a (show EIF6 Proteins) and eIF3c control abundance and assembly of the entire eIF3 (show EIF3A Proteins) and thus represent its crucial scaffolding elements critically required for formation of preinitiation complexes.
eukaryotic initiation factor 4G (eIF4G (show EIF4G1 Proteins)) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.
Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy.
These results indicate that the interaction between Hsp90 (show HSP90 Proteins) and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity).
eukaryotic translation initiation factor 3 subunit 8
, eukaryotic translation initiation factor 3 subunit C
, eukaryotic translation initiation factor 3, subunit 8, 110kDa
, eIF3 p110
, Eukaryotic translation initiation factor 3 subunit 8
, eIF3-S8 protein
, Eukaryotic translation initiation factor 3 subunit C
, cell migration-inducing protein 17
, eukaryotic translation initiation factor 3, subunit 8 (110kD)
, NIPI-like protein
, eukaryotic translation initiation factor 3, subunit 8 (110 kDa)
, extra-toes spotting
, eukaryotic translation initiation factor 3, subunit C