Browse our Gem (Nuclear Organelle) Associated Protein 2 Proteins (GEMIN2)

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Gem (Nuclear Organelle) Associated Protein 2 Proteins (GEMIN2)
On www.antibodies-online.com are 6 Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) Proteins from 4 different suppliers available. Additionally we are shipping Gem (Nuclear Organelle) Associated Protein 2 Antibodies (83) and Gem (Nuclear Organelle) Associated Protein 2 Kits (1) and many more products for this protein. A total of 100 Gem (Nuclear Organelle) Associated Protein 2 products are currently listed.
Synonyms:
1700012N19Rik, HSPC082, SIP-1, Sip1, SIP1-delta, SMADIP1, ZFHX1B
list all proteins Gene Name GeneID UniProt
GEMIN2 8487 O14893
GEMIN2 66603 Q9CQQ4
GEMIN2 84404 Q9QZP1

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Gem (Nuclear Organelle) Associated Protein 2 Proteins (GEMIN2) by Origin

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More Proteins for Gem (Nuclear Organelle) Associated Protein 2 Interaction Partners

Human Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) interaction partners

  1. siRNAs targeting Ets1 repressed expression of ZEB1/ZEB2.

  2. overexpression of miR (show MLXIP Proteins)-218 in H1299 increased chemosensitivity of cells to cisplatin treatment through suppression of Slug (show SNAI2 Proteins) and ZEB2. These findings highlight an important role of miR (show MLXIP Proteins)-218 in the regulation of EMT (show ITK Proteins)-related traits and metastasis of lung cancer in part by modulation of Slug (show SNAI2 Proteins)/ZEB2 signaling, and provide a potential therapeutic strategy by targeting miR (show MLXIP Proteins)-218 in lung cancer.

  3. results revealed the critical regulatory role of miR-145 in hepatic stellates cells activation and implied miR-145 as a potential candidate for therapy of hepatic fibrosis by regulation of Wnt/beta-catenin through targeting ZEB2

  4. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.

  5. Results show that inhibition of miR-141 enhanced colorectal cancer (CRC) cell proliferation and migration through significant increase of its target's expression, ZEB2 and phosphorylation of HGFR.

  6. This Gene-based tests suggest evidence of association with related genes, ZEB2, RND3 (show RND3 Proteins), MCTP1, CTBP2 (show CTBP2 Proteins), and beta EEG.

  7. Collectively, the results demonstrate that Zeb2 controls adult hematopoietic differentiation and lineage fidelity through widespread modulation of dominant signaling pathways that may contribute to blood disorders.

  8. ZEB2 transcriptionally represses genes that regulate myeloid differentiation, including genes involved in cell adhesion and migration; epigenetic silencing of the miR-200 family microRNAs affects ZEB2 expression.

  9. This study identified the lysine-specific demethylase (show MBD2 Proteins) KDM1A (show KDM1A Proteins) as a novel interaction partner of ZEB2 and demonstrated that mouse and human T-cell acute lymphoblastic leukemia cells with increased ZEB2 levels critically depend on KDM1A (show KDM1A Proteins) activity for survival.

  10. e revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.

Mouse (Murine) Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) interaction partners

  1. utilised a targeted screen to identify mRNA associated with SMN (show STMN1 Proteins), Gemin2 and Gemin3 (show DDX20 Proteins) in the cytoplasm of a human neuroblastoma (show ARHGEF16 Proteins) cell line, SHSY5Y

  2. Gene targeting in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death (gemin2; SMN interacting protein 1)

Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2)

  • gem (nuclear organelle) associated protein 2 (gemin2)
  • gem (nuclear organelle) associated protein 2 (GEMIN2)
  • gem (nuclear organelle) associated protein 2 (Gemin2)
  • zinc finger E-box binding homeobox 2 (ZEB2)
  • 1700012N19Rik protein
  • HSPC082 protein
  • SIP-1 protein
  • Sip1 protein
  • SIP1-delta protein
  • SMADIP1 protein
  • ZFHX1B protein

Protein level used designations for GEMIN2

SMN-interacting protein 1 , Survival of motor neuron protein-interacting protein 1 , component of gems 2 , gem-associated protein 2 , gemin-2 , survival of motor neuron protein interacting protein 1 , SMN interacting protein 1-delta , survival of motor neuron protein-interacting protein 1 , survivor of motor neuron protein interacting protein 1 , SMN interacting protein-1 , SMAD interacting protein 1 , Smad-interacting protein 1 , zinc finger E-box-binding homeobox 2 , zinc finger homeobox 1b

GENE ID SPECIES
494588 Xenopus laevis
8487 Homo sapiens
510259 Bos taurus
66603 Mus musculus
84404 Rattus norvegicus
423336 Gallus gallus
610087 Canis lupus familiaris
9839 Homo sapiens
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