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Human Polyclonal PRPF19 Primary Antibody for ELISA, WB - ABIN565380
Ilagan, Chalkley, Burlingame, Jurica: Rearrangements within human spliceosomes captured after exon ligation. in RNA (New York, N.Y.) 2013
Human Polyclonal PRPF19 Primary Antibody for ICC, IF - ABIN441360
Beck, Park, Lee, Roman, Hromas, Lee: Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair. in The Journal of biological chemistry 2008
Cow (Bovine) Polyclonal PRPF19 Primary Antibody for IHC, WB - ABIN2773819
Voglauer, Chang, Dampier, Wieser, Baumann, Sterovsky, Schreiber, Katinger, Grillari: SNEV overexpression extends the life span of human endothelial cells. in Experimental cell research 2006
Show all 2 Pubmed References
Crystal structure revealed features of the WD40 domain (show DCAF12L2 Antibodies) of human PRPF19.
The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.
role of Pso4 in DNA repair and DNA damage
Study demonstrates that the levels of Prp19 and Cdc5L (show CDC5L Antibodies) are overexpressed in hepatocellular carcinoma (HCC (show FAM126A Antibodies)). Prp19 binds with Cdc5L (show CDC5L Antibodies) and its downregulation results in reduction of Cdc5L (show CDC5L Antibodies). Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L (show CDC5L Antibodies) and facilitates lysosome-induced degradation of Cdc5L (show CDC5L Antibodies) in HCC (show FAM126A Antibodies) cells.
We report that PRP19 expression is elevated in lung carcinoma tissues compared to non-tumor tissues
These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19.
involvement of hPso4 in the recombinational repair of DSBs
DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells.
The Prp19-CDC5L (show CDC5L Antibodies) complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome.
Prp19 complex as the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase.
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA-induced senescence in mouse skin
the alpha-variant of Prp19 gene plays a pivotal role in neural differentiation and that the beta-variant participates in neuronal/astroglial cell fate decisions
Down-regulation of Prp19p expression with RNA interference in 3T3-L1 cells repressed lipid droplet formation with the reduction in the level of expression of perilipin (show PLIN1 Antibodies) and S3-12 (show PLIN4 Antibodies)
SNEV is indispensable for early mouse development; MEFs (mouse embryonic fibroblasts) with reduced SNEV levels have lowered proliferative potential.
Immunofluorescence microscopy revealed that a domain of amino acids 167-250 is necessary for the recruitment of Prp19p to lipid droplets and that a domain of amino acids 1-166 is necessary for the recruitment of Prp19p to a nucleus.
The expression of SNEV is closely associated with the growth of murine hematopoietic stem cells (HSCs) and determines the proliferative and repopulating capacity of phenotypically defined HSC (show FUT1 Antibodies) subsets.
The knockdown of PRPF19 or EIF4A3 (show EIF4A3 Antibodies) decreased splicing of Lhb (show LHB Antibodies), or of both beta subunit (show POLG Antibodies) transcripts, respectively.
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008
pre-mRNA-processing factor 19
, nuclear matrix protein NMP200 related to splicing factor PRP19
, PRP19/PSO4 pre-mRNA processing factor 19 homolog
, PRP19/PSO4 homolog
, nuclear matrix protein 200
, senescence evasion factor
, neuronal differentiation-related gene protein
, pre-mRNA processing factor 19
, nuclear matrix protein SNEV
, prp19 beta