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Data indicate that MEP50 WD repeat protein (show DCAF7 Proteins) is essential for methylation of histones H4 and H2A (show H2AFX Proteins) by PRMT5 (show PRMT5 Proteins) arginine methyltransferase.
Structure of MEP50/Wdr77 in the PRMT5 (show PRMT5 Proteins)-MEP50 complex
Protein arginine methyltransferase Prmt5 (show PRMT5 Proteins)-Mep50 methylates histones H2A (show H2AFX Proteins) and H4 and the histone chaperone nucleoplasmin (show NPM1 Proteins) in Xenopus laevis eggs
TSC22D2 protein might be a member of the PRMT5 (show PRMT5 Proteins) complex via direct binding of WDR77.
MEP50 genes reduces gene expression through histone arginine methylation in keratinocytes.
MEP50 can transform cells independent of AR and ER.
Data indicate that MEP50 WD repeat protein (show DCAF7 Proteins) is essential for methylation of histones H4 and H2A by PRMT5 (show PRMT5 Proteins) arginine methyltransferase.
These findings characterize PKG (show PRKG1 Proteins) as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.
Data indicate a transcription complex androgen receptor (AR (show AR Proteins))-p44 (show GTF2H2 Proteins)-Smad1 (show GARS Proteins), and confirmed for physical interaction by co-immunoprecipitaion.
These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by WDR77's location in the cell.
structure of the surprising hetero-octameric complex reveals the close interaction between the seven-bladed beta-propeller MEP50 and the N-terminal domain of PRMT5 (show PRMT5 Proteins), and delineates the structural elements of substrate recognition.
p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis.
expression and function of p44 in breast cancer; expression of p44 shows strong cytoplasmic expression in morphologically normal terminal ductal lobular units, while nuclear p44 is observed in both ductal carcinoma in situ and invasive carcinoma
Silencing p21(Cip1 (show CDKN1A Proteins)) or NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) expression with short hairpin RNA (shRNA) abolished astrocyte activation and rescued the astrocyte growth inhibition induced by deletion of the p44/WDR77 gene.
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002
WD repeat-containing protein 77
, methylosome protein 50
, WD repeat domain 77
, methylosome protein 50-like
, androgen receptor cofactor p44