Browse our Patatin-Like phospholipase Domain Containing 6 Proteins (PNPLA6)

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Patatin-Like phospholipase Domain Containing 6 Proteins (PNPLA6)
On www.antibodies-online.com are 7 Patatin-Like phospholipase Domain Containing 6 (PNPLA6) Proteins from 4 different suppliers available. Additionally we are shipping Patatin-Like phospholipase Domain Containing 6 Antibodies (68) and Patatin-Like phospholipase Domain Containing 6 Kits (10) and many more products for this protein. A total of 92 Patatin-Like phospholipase Domain Containing 6 products are currently listed.
Synonyms:
AI661849, CALJA, CD73, CG2212, Dmel\\CG2212, E5NT, eN, eNT, iPLA2delta, MSws, NT, NT5, Nte, NTEMND, olfE, RGD1564611, SPG39, sws, wu:fy20f06
list all proteins Gene Name GeneID UniProt
PNPLA6 4907 P21589
PNPLA6 50767 Q3TRM4
PNPLA6 360753  

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Patatin-Like phospholipase Domain Containing 6 Proteins (PNPLA6) by Origin

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More Proteins for Patatin-Like phospholipase Domain Containing 6 Interaction Partners

Fruit Fly (Drosophila melanogaster) Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. the loss of SWS in glia impairs neuronal function.

  2. inducible, neuron-specific expression of full-length human wildtype NTE reduces vacuole formation and substantially rescues mobility.

  3. OP-modified SWS cannot release PKA-C3 and the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of organophosphate-induced delayed neuropathy but not in the acute toxicity

Human Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. CD73 expression is upregulated in NSCLC and is correlated with a decrease in miR (show MLXIP Proteins)-30a-5p expression.

  2. These results strongly suggest that PNPLA9 (show PLA2G6 Proteins), -6 and -4 play a key role in GPL (show IL31RA Proteins) turnover and homeostasis in human cells. A hypothetical model suggesting how these enzymes could recognize the relative concentration of the different GPLs is proposed

  3. concluded that CD39 (show ENTPD1 Proteins) and CD73 are molecular targets for the development of drugs for ALF (show GTF2A1L Proteins) patients care

  4. Genetic polymorphism of NT5E (show NT5E Proteins) may contribute to the pathogenesis of calcific aortic valve disease.

  5. Oxidized low density lipoproteins modulate CD39 (show ENTPD1 Proteins) and CD73 activity in the endothelium.

  6. The unusual medical history with childhood ataxia (show USP14 Proteins) and hypogonadotropic hypogonadism lead to further examinations and eventually the diagnosis of BNS. The older sister of the proband also displayed the triad of ataxia (show USP14 Proteins), HH and chorioretinal dystrophy accompanied by cerebellar atrophy and in 2014, we found the mutations in PNPLA6.

  7. This study aimed to investigate the activities of purinergic system ecto (show TRIM33 Proteins)-enzymes present on the platelet surface as well as CD39 (show ENTPD1 Proteins) and CD73 expressions on platelets of sickle cell anemia treated patients.

  8. Data indicate two novel homozygous mutations (one frameshift and one missense mutation) detected in CYP7B1 (SPG5A (show CYP7B1 Proteins)), while no disease-causing mutation was identified for PNPLA6 (SPG39) and C19orf12 (SPG43).

  9. CD73 promotes the growth of human colorectal cancer cells through EGFR (show EGFR Proteins) and the b-catenin/cyclin D1 (show CCND1 Proteins) signaling pathway. CD73 may be used as a valuable biomarker of colorectal cancer.

  10. The NT5E (show NT5E Proteins) gene is involved in both intrinsic and acquired resistance to platinum-based drugs in ovarian cancer. [meta-analysis]

Mouse (Murine) Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. the expression of CaMKIIalpha and pCREB exhibits a significant increase in cortex and hippocampus after treatment with PFOS, compared with the control.

  2. NTE has a role in neural development and in the neurodegeneration induced by organophosphate compounds in mice

  3. mouse brain neuropathy target esterase is a lysophospholipase

  4. impairment of vasculogenesis in the yolk sacs and embryos of null mutant conceptuses suggested that NTE is required for normal blood vessel development

  5. Increase of neuropathy target esterase (NTE) expression contributes to increased production and accumulation of glycerophosphocholine in mammalian renal cells in tissue culture and in vivo.

  6. We conclude that spongiform pathology in conditional NTE knockout mice is not mediated by PrPc (show PRNP Proteins), and that tubulovesicular inclusions can be seen in spongiform encephalopathy of other etiologies and are not pathognomonic of prion (show PRNP Proteins) disease

Patatin-Like phospholipase Domain Containing 6 (PNPLA6) Protein Profile

Protein Summary

This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Patatin-Like phospholipase Domain Containing 6 (PNPLA6)

  • swiss cheese (sws)
  • 5'-nucleotidase, ecto (CD73) (NT5E)
  • patatin-like phospholipase domain containing 6 (pnpla6)
  • patatin-like phospholipase domain containing 6 (PNPLA6)
  • patatin-like phospholipase domain containing 6 (Pnpla6)
  • AI661849 protein
  • CALJA protein
  • CD73 protein
  • CG2212 protein
  • Dmel\\CG2212 protein
  • E5NT protein
  • eN protein
  • eNT protein
  • iPLA2delta protein
  • MSws protein
  • NT protein
  • NT5 protein
  • Nte protein
  • NTEMND protein
  • olfE protein
  • RGD1564611 protein
  • SPG39 protein
  • sws protein
  • wu:fy20f06 protein

Protein level used designations for PNPLA6

CG2212-PA , CG2212-PB , CG2212-PC , olfactory E , olfactory-E , swiss-cheese , swisscheese , sws-PA , sws-PB , sws-PC , 5'-NT , 5'-nucleotidase , Purine 5-Prime-Nucleotidase , ecto-5'-nucleotidase , nte , neuropathy target esterase , patatin-like phospholipase domain-containing protein 6 , Swiss cheese , Swiss-cheese

GENE ID SPECIES
31716 Drosophila melanogaster
4907 Homo sapiens
386860 Danio rerio
10908 Homo sapiens
50767 Mus musculus
425396 Gallus gallus
484993 Canis lupus familiaris
100524423 Sus scrofa
767822 Bos taurus
360753 Rattus norvegicus
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