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Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability.
Angptl4 (show ANGPTL4 Proteins) is a glucocorticoid-responsive mediator of fasting-induced (show C10orf10 Proteins) intracellular lipolysis and stimulates cAMP signaling in adipocytes
Angiopoietin-3 binds to the cell membrane via heparan sulfate proteoglycans
Recombinant Ang3 formed disulfide-linked dimers. Ang3 was more potent than Ang4 in phosphorylating Akt in primary cultured mouse lung microvascular endothelial cells. It (show TEK Proteins) is a Tie2 agonist & causes corneal angiogenesis.
angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure
Aberrant expression of ANGPTL1 (show ANGPTL1 Proteins) in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome.
Retinoic acid receptor beta (show RARB Proteins) and angiopoietin-like protein 1 (show ANGPTL1 Proteins) are involved in the regulation of human androgen biosynthesis
acute-phase protein (show ORM1 Proteins) A1AT (show SERPINA1 Proteins) is a physiological regulator of angptl4 (show ANGPTL4 Proteins), another acute-phase protein (show ORM1 Proteins).
ANGPTL1 (show ANGPTL1 Proteins) represses lung cancer cell motility by abrogating the expression of the epithelial mesenchymal transformation mediator SLUG (show SNAI2 Proteins).
In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival.
Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported.
Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells.
Immunohistochemical staining of Ang-1 was observed in smooth muscle cells, whereas Ang-2 was detected in endothelial cells, smooth muscle cells and macrophages.
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.
, angiopoietin 3
, dJ824F16.2 (angiopoietin 4)
, angiopoietin-like protein 4
, angiopoietin Y1
, angiopoietin-like protein 1
, angiopoietin-related protein 1
, dJ595C2.2 (angiopoietin Y1)