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anti-Human BDNF Antibodies:
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Dog (Canine) Polyclonal BDNF Primary Antibody for IHC, WB - ABIN2777093
Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. in Neuroscience research 2008
Show all 7 Pubmed References
Human Polyclonal BDNF Primary Antibody for CyTOF, FACS - ABIN4899237
Xapelli, Bernardino, Ferreira, Grade, Silva, Salgado, Cavadas, Grouzmann, Poulsen, Jakobsen, Oliveira, Zimmer, Malva: Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. in The European journal of neuroscience 2008
Show all 5 Pubmed References
Human Polyclonal BDNF Primary Antibody for ICC, IF - ABIN409162
Atasoy, Dursun, Gezen-Ak, Metin-Armağan, Öztürk, Yılmazer: Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. in Journal of chemical neuroanatomy 2016
Show all 2 Pubmed References
Human Polyclonal BDNF Primary Antibody for EIA, WB - ABIN115984
Hartog, Dittrich, Pieneman, Jansen, Frankl-Vilches, Lessmann, Lilliehook, Goldman, Gahr: Brain-derived neurotrophic factor signaling in the HVC is required for testosterone-induced song of female canaries. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Human Polyclonal BDNF Primary Antibody for EIA, Func - ABIN115985
Miknyoczki, Wan, Chang, Dobrzanski, Ruggeri, Dionne, Buchkovich: The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice. in Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Show all 3 Pubmed References
Human Polyclonal BDNF Primary Antibody for EIA, Func - ABIN115986
Wirth, Patz, Wahle: Transcellular induction of neuropeptide Y expression by NT4 and BDNF. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Monoclonal BDNF Primary Antibody for ICC, ELISA - ABIN1724944
Yoshida, Ishikawa, Niitsu, Nakazato, Watanabe, Shiraishi, Shiina, Hashimoto, Kanahara, Hasegawa, Enohara, Kimura, Iyo, Hashimoto: Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. in PLoS ONE 2012
Human Polyclonal BDNF Primary Antibody for IF (p), IHC (p) - ABIN1387788
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Human Monoclonal BDNF Primary Antibody for FACS, ICC - ABIN4283827
Lambert, Carlson, Formichella, Sappington, Ahlem, Calkins: Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. in Frontiers in neuroscience 2017
In conclusion, BDNF 196G/A genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study. BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.
BDNF promotes hESC-NSC growth in vitro through crosstalk with the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
We discuss methodological shortcomings of our study and potential differences in the temporal dynamics of how IGF-1 (show IGF1 Antibodies), VEGF (show VEGFA Antibodies) and BDNF may be affected by exercise and to what extent these differences may have led to the negative findings reported here.
Patients affected by depressive disorders showed an increase of brain-derived neurotrophic factor serum concentration after a 2-week treatment with agomelatine. The increase of brain-derived neurotrophic factor levels was found to be greater in patients with lower brain-derived neurotrophic factor levels and marked anhedonia at baseline.
There was a positive correlation between BDNF and progesterone in controls. In conclusion, primary pvarian insufficiency(POI) patients show significantly lower BDNF plasma concentration and it correlates with the duration of amenorrhea. This observation brings important potential insights to the pathology of POI.
Most biomarkers (IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), TNF-alpha (show TNF Antibodies), TBARS and protein carbonyl) and BDNF did not differ significantly between patients and controls.
Authors modeled the long-term effects of chronic stress exposure in a novel mouse model that has been genetically modified to express a humanized BDNF (hBDNF) coding transcript via endogenous mouse promoters that has yet to be behaviorally phenotyped.
The aim of the current review was to provide an overview of the role of BDNF/TrkB (show NTRK2 Antibodies) pathways in the pathogenesis of breast cancer and its value as a potential therapeutic target.
We hypothesize that BDNF in the developing brain regulates fear circuit plasticity during a sensitive period in early adolescence, and alterations in BDNF expression (genetic or environmental) have a persistent impact on fear behavior and fear-related disorders.
BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.
A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B (show NTRK2 Antibodies) signaling in the hippocampus and enhances depression-like behaviors later in life.
Deletion of Bdnf in DRG neurons leads to a temporary dysregulation of miR-1.
Excitatory synaptic activation-dependent up-regulation of XBP1 (show XBP1 Antibodies) directly facilitated transcriptional activation of BDNF. BDNF in turn drove its own expression via IRE1 (show ERN1 Antibodies)-XBP1 (show XBP1 Antibodies) pathway in a protein kinase A-dependent manner. Exogenous treatment with BDNF promoteSynaptic activity- and BDNF-dependent distinct activation of dendritic IRE1 (show ERN1 Antibodies)-XBP1 (show XBP1 Antibodies) cascade drives BDNF expression in cell soma and may be involved in dendritic extension.
High BDNF expression is associated with neuropathic pain.
The authors show that BDNF acts cell autonomous and autocrine, as wildtype neurons are not capable of rescuing growth deficits in neighboring MeCP2 deficient neurons in vitro and in vivo.
BDNF acts retrogradely on TrkB (show NTRK2 Antibodies) in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week.
EGCG significantly ameliorated insulin (show INS Antibodies) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (show IRS1 Antibodies))/AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathways.
CTCF (show CTCF Antibodies) knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF and Arc (show NOL3 Antibodies) loci.
Results suggest that activity-dependent BDNF signaling is critical for regulating oscillatory activity, which may contribute to altered behavior.
One of the modulators of TOR (show FRAP1 Antibodies) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Antibodies) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Antibodies) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Antibodies) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Antibodies) influences the expression level of components of chemokine (show CCL1 Antibodies) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Antibodies) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Antibodies) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Antibodies)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Antibodies) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Antibodies) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Antibodies) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Antibodies)-derived alphaMSH (show POMC Antibodies), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Antibodies) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Antibodies) and MMP-2 (show MMP2 Antibodies), caspase-3 (show CASP3 Antibodies) and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Antibodies) and leptin (show LEP Antibodies).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Antibodies) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Antibodies) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
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