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anti-Human BDNF Antibodies:
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Dog (Canine) Polyclonal BDNF Primary Antibody for IHC, WB - ABIN2777093
Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. in Neuroscience research 2008
Show all 7 Pubmed References
Human Polyclonal BDNF Primary Antibody for CyTOF, FACS - ABIN4899237
Xapelli, Bernardino, Ferreira, Grade, Silva, Salgado, Cavadas, Grouzmann, Poulsen, Jakobsen, Oliveira, Zimmer, Malva: Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. in The European journal of neuroscience 2008
Show all 5 Pubmed References
Human Polyclonal BDNF Primary Antibody for ICC, IF - ABIN409162
Atasoy, Dursun, Gezen-Ak, Metin-Armağan, Öztürk, Yılmazer: Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. in Journal of chemical neuroanatomy 2016
Show all 2 Pubmed References
Human Monoclonal BDNF Primary Antibody for ICC, ELISA - ABIN1724944
Yoshida, Ishikawa, Niitsu, Nakazato, Watanabe, Shiraishi, Shiina, Hashimoto, Kanahara, Hasegawa, Enohara, Kimura, Iyo, Hashimoto: Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. in PLoS ONE 2012
Human Polyclonal BDNF Primary Antibody for IF (p), IHC (p) - ABIN1387788
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Human Polyclonal BDNF Primary Antibody for EIA, Func - ABIN115985
Hartog, Dittrich, Pieneman, Jansen, Frankl-Vilches, Lessmann, Lilliehook, Goldman, Gahr: Brain-derived neurotrophic factor signaling in the HVC is required for testosterone-induced song of female canaries. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 3 Pubmed References
Human Polyclonal BDNF Primary Antibody for EIA, Func - ABIN115986
Miknyoczki, Wan, Chang, Dobrzanski, Ruggeri, Dionne, Buchkovich: The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice. in Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Show all 3 Pubmed References
Dog (Canine) Polyclonal BDNF Primary Antibody for WB - ABIN2777092
Galindo, Soslow, Brinkmeyer-Langford, Gupte, Smith, Sengsayadeth, Sawyer, Benson, Kornegay, Markham: Translating golden retriever muscular dystrophy microarray findings to novel biomarkers for cardiac/skeletal muscle function in Duchenne muscular dystrophy. in Pediatric research 2016
One of the modulators of TOR (show FRAP1 Antibodies) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Antibodies) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Antibodies) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Antibodies) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Antibodies) influences the expression level of components of chemokine (show CCL1 Antibodies) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Antibodies) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Antibodies) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Antibodies)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Antibodies) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Antibodies) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Antibodies) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Antibodies)-derived alphaMSH (show POMC Antibodies), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Antibodies) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Antibodies) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Antibodies) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
Results suggest that activity-dependent BDNF signaling is critical for regulating oscillatory activity, which may contribute to altered behavior.
the transcriptional induction of Bdnf by a mnemonic stimulus is impaired in aged hippocampal neurons.
BDNF deficiency results in depression-like behavior, regardless of age and gender.
Study reports that an endogenous molecule released after exercise is capable of inducing key promoters of the Mus (show TRPV6 Antibodies) musculus Bdnf gene. The metabolite beta-hydroxybutyrate, which increases after prolonged exercise, induces the activities of Bdnf promoters, particularly promoter I, which is activity-dependent.
Results show that (1) large-soma retinal ganglion cells are particularly susceptible to optic nerve injury; and (2) overexpression of BDNF prolongs the survival of retinal ganglion cells, including large-soma retinal ganglion cells.
GR downregulates Bdnf expression through direct binding to Bdnf regulatory sequences.
BDNF, a neurotrophic peptide essential for learning and memory, is down-regulated by tau proatein.
that brain-specific (show CALY Antibodies) deletion of Efr3a (show EFR3A Antibodies) could promote adult hippocampal neurogenesis, presumably by upregulating the expression of BDNF and its receptor
Brain and liver Bdnf mRNA showed a 12-h phase shift when fed ketogenic diet (KD) compared with high-fat diet (HFD) or low-fat diet (LFD).
In vivo reduced levels of GSK3beta (show GSK3b Antibodies) phosphorylation in the retinal tissues of the BDNF(+/-) animals implicating critical role of BDNF in the regulation of the GSK3beta (show GSK3b Antibodies) activity.
BDNF allelic risk may play a role in predicting cognitive change.
Role of the rs10767664 variant on outcomes after biliopancreatic diversion surgery. Weight loss, blood pressure, low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, insulin (show INS Antibodies) and homeostasis model assessment for insulin (show INS Antibodies) resistance (HOMA-IR) improved. No differences in these changes were detected between the two genotypes (wild-type group AA vs. mutant group AT plus TT) in a dominant model.
Findings indicate that BDNF val66met carriers have increased subcortical 5-HTT-SERT (show SLC6A4 Antibodies) binding.
The Met allele of the BDNF gene was not more frequent in patients compared with controls, but was associated to an increased frequency of SCR (P=0.008) in response to cues for starvation.
BDNF may be a female-specific risk gene for Alzheimer's disease.
These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns.
Data suggest that high expression of TRKB (show NTRK2 Antibodies) (not TRKA (show NTRK1 Antibodies) or TRKC (show NTRK3 Antibodies)) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB (show NTRK2 Antibodies)-high expression is significantly shorter than those with TRKB (show NTRK2 Antibodies)-low expression; RNA interference against TRKB (show NTRK2 Antibodies) or BDNF (TRKB (show NTRK2 Antibodies) agonist) inhibits cell proliferation of tumor cell line.
Data suggest that, in hippocampal neurons, BDNF plays vital role in long-term potentiation (an aspect of neuronal plasticity). [REVIEW]
Data suggest that BDNF propeptide and BDNF exhibit antagonistic functions in long-term synaptic depression (LTD), i.e., facilitation and blockade of LTD induction (one aspect of synaptic plasticity). [REVIEW]
Data suggest that zinc interactions with BDNF and BDNF peptide fragments are important in zinc metallostasis in the brain during aging. [REVIEW]
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Antibodies) and leptin (show LEP Antibodies).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Antibodies) and MMP-2 (show MMP2 Antibodies), caspase-3 (show CASP3 Antibodies) and BDNF
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor