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|Application / Reactivity||Human|
|Cell-ELISA (cELISA)||1 Antibodies|
|Dot Blot (DB)||18 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||23 Antibodies|
|Functional Studies (Func)||1 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||17 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||24 Antibodies|
|Immunohistochemistry (IHC)||41 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||34 Antibodies|
|Immunoprecipitation (IP)||6 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Western Blotting (WB)||151 Antibodies|
|Antigen||EPH Receptor A2 (EPHA2) Antibodies|
|Conjugate||This EPH Receptor A2 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
|5 references available|
|Supplier||Log in to see|
Product Details anti-EPH Receptor A2 AntibodyTarget Details EPH Receptor A2 Application Details Handling References for anti-EPH Receptor A2 Antibody (ABIN2664953) Images
|Purification||The antibody was purified by affinity chromatography.|
Target Details EPH Receptor A2Product Details anti-EPH Receptor A2 Antibody Application Details Handling References for anti-EPH Receptor A2 Antibody (ABIN2664953) Images back to top
|Alternative Name||EphA2 (EPHA2 Antibody Abstract)|
|Background||Ephrin receptor A2 (EphA2), also known as Eck, is a 130 kD type I transmembrane glycoprotein which belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA2 is expressed on epithelial cells, keratinocytes, dendritic/Langerhans cells and melanocytes. It has also been observed in breast, cervical, ovarian, prostate, colon, skin and lung cancers. EphA2 is an oncoprotein which is an essential survival factor for many melanomas. EphA2 plays an important role in angiogenesis and tumor neovascularization through interaction with ephrin-A1, -A3, -A4 and -A5.|
Application DetailsProduct Details anti-EPH Receptor A2 Antibody Target Details EPH Receptor A2 Handling References for anti-EPH Receptor A2 Antibody (ABIN2664953) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-EPH Receptor A2 Antibody Target Details EPH Receptor A2 Application Details References for anti-EPH Receptor A2 Antibody (ABIN2664953) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-EPH Receptor A2 Antibody (ABIN2664953)Product Details anti-EPH Receptor A2 Antibody Target Details EPH Receptor A2 Application Details Handling Images back to top
Udayakumar, Zhang, Ji et al.: "EphA2 is a critical oncogene in melanoma." in: Oncogene, Vol. 30, Issue 50, pp. 4921-9, 2011 (PubMed).
Brantley-Sieders, Zhuang, Hicks et al.: "The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling." in: The Journal of clinical investigation, Vol. 118, Issue 1, pp. 64-78, 2008 (PubMed).
Pratt, Kinch: "Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade." in: Oncogene, Vol. 21, Issue 50, pp. 7690-9, 2002 (PubMed).
Sulman, Tang, Allen et al.: "ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers." in: Genomics, Vol. 40, Issue 2, pp. 371-4, 1997 (PubMed).
Pandey, Lazar, Saltiel et al.: "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity." in: The Journal of biological chemistry, Vol. 269, Issue 48, pp. 30154-7, 1994 (PubMed).
ImagesProduct Details anti-EPH Receptor A2 Antibody Target Details EPH Receptor A2 Application Details Handling References for anti-EPH Receptor A2 Antibody (ABIN2664953) back to top