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Mouse (Murine) GAS6 ELISA Kit for Sandwich ELISA - ABIN1889367
Angelillo-Scherrer, de Frutos, Aparicio, Melis, Savi, Lupu, Arnout, Dewerchin, Hoylaerts, Herbert, Collen, Dahlbäck, Carmeliet: Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. in Nature medicine 2001
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Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 (show MAPK1/3 ELISA Kits) signaling.
Gas6/Axl (show AXL ELISA Kits) and Akt (show AKT1 ELISA Kits)/FoxO1a (show FOXO1 ELISA Kits) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 ELISA Kits) signaling axis plays an important role in VCAM-1 (show VCAM1 ELISA Kits) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL ELISA Kits) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES ELISA Kits)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL ELISA Kits) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL ELISA Kits) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 ELISA Kits)/FoxO (show FOXO3 ELISA Kits) signaling pathway.
The up-regulation of Gas6/Axl (show AXL ELISA Kits) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 ELISA Kits) signaling requires coincident TAM (show CCNA1 ELISA Kits) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 ELISA Kits) receptor tyrosine kinases Tyro3 (show TYRO3 ELISA Kits), Axl (show AXL ELISA Kits), and Mer (show ERH ELISA Kits) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH ELISA Kits) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
Data show that the variant growth arrest specific 6 (GAS6) +1332 T allele is associated with a decreased risk for severe preeclampsia in a South West Han Chinese population, but the 834+7G/A polymorphism has no effect on the severe preeclampsia.
Gas6 plasma level within 24 hours of ICU admission may predicts in-ICU mortality in patients with sepsis
Taken together, these results indicate that E2 exerts inhibitory effects on VSMC apoptosis and calcification through ERalpha (show ESR1 ELISA Kits)-mediated Gas6 transactivation. These findings indicate a potential therapeutic strategy for the prevention of vascular calcification, especially in postmenopausal women.
In this paper, we review the biology of the Gas6/Tyro3 (show TYRO3 ELISA Kits), Axl (show AXL ELISA Kits), and MerTK (show MERTK ELISA Kits)(collectively named TAM (show CCNA1 ELISA Kits) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
serum testosterone and GAS6 levels were positively associated in male patients with coronary heart disease
investigation of the prognostic values of stromal NK cells and Gas6 in triple negative breast cancer (TNBC), and to eventually establish a prognostic risk model for patients with TNBC
CONCLUSIONS: Our results suggest that GAS6 c.834 + 7G> A polymorphism may have a pivotal role in the pathogenesis of preeclampsia (PE) suggesting that the A allele has a protective role for PE.
High expression of Gas6 correlated with Upper Tract Urothelial Carcinoma.
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor