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|Application / Reactivity||Human|
|Cellular Assay (CA)||1 Antibodies|
|Dot Blot (DB)||192 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||17 Antibodies|
|Flow Cytometry (FACS)||133 Antibodies|
|Functional Studies (Func)||5 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Immunochromatography (IC)||5 Antibodies|
|Immunocytochemistry (ICC)||12 Antibodies|
|Immunoelectron Microscopy (IEM)||6 Antibodies|
|Immunofluorescence (IF)||215 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||93 Antibodies|
|Immunohistochemistry (IHC)||317 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||5 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||2 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||3 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||45 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||182 Antibodies|
|Antigen||V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies|
|Conjugate||This HER2 antibody is un-conjugated Alternatives|
Dot Blot (DB), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-HER2 AntibodyTarget Details HER2 Application Details Handling References for anti-HER2 Antibody (ABIN1881305) Images
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This ErbB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1248 of human ErbB2.|
Target Details HER2Product Details anti-HER2 Antibody Application Details Handling References for anti-HER2 Antibody (ABIN1881305) Images back to top
|Alternative Name||ERBB2 (ERBB2 Antibody Abstract)|
ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
Synonyms: Receptor tyrosine-protein kinase erbB-2 [Precursor], p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, ERBB2, HER2, NEU, NGL,
|NCBI Accession||NP_001005862, NP_004439|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-HER2 Antibody Target Details HER2 Handling References for anti-HER2 Antibody (ABIN1881305) Images back to top
|Application Notes||WB: 1:8000,DB: 1:500|
|Restrictions||For Research Use only|
HandlingProduct Details anti-HER2 Antibody Target Details HER2 Application Details References for anti-HER2 Antibody (ABIN1881305) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-HER2 Antibody (ABIN1881305)Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
|Product cited in:||
Yee, Young, Rosol et al.: "Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone." in: The Journal of nutrition, Vol. 135, Issue 5, pp. 983-8, 2005 (PubMed).
Brandt, Mikesch, Simon et al.: "Selective expression of a splice variant of decay-accelerating factor in c-erbB-2-positive mammary carcinoma cells showing increased transendothelial invasiveness." in: Biochemical and biophysical research communications, Vol. 329, Issue 1, pp. 318-23, 2005 (PubMed).
Provinciali, Re, Donnini et al.: "Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice." in: International journal of cancer. Journal international du cancer, Vol. 115, Issue 1, pp. 36-45, 2005 (PubMed).
Ghatak, Misra, Toole: "Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells." in: The Journal of biological chemistry, Vol. 280, Issue 10, pp. 8875-83, 2005 (PubMed).
Beckers, Herrmann, Rieger et al.: "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis." in: International journal of cancer. Journal international du cancer, Vol. 114, Issue 4, pp. 590-7, 2005 (PubMed).
ImagesProduct Details anti-HER2 Antibody Target Details HER2 Application Details Handling References for anti-HER2 Antibody (ABIN1881305) back to top