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anti-Human HER2 antibody for Functional Studies

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • c-erbB2
  • c-neu
  • CD340
  • Erbb-2
  • HER-2
  • HER-2/neu
  • HER2
  • mKIAA3023
  • MLN 19
  • NEU
  • Neu
  • NGL
  • TKR1
Epitope
Extracellular Domain
120
83
64
54
53
53
51
44
37
36
32
29
21
20
20
20
20
19
19
19
19
19
19
18
18
18
15
14
14
14
13
13
13
12
10
10
9
8
8
8
8
7
7
7
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1322
418
261
24
13
4
3
3
3
3
2
2
1
1
1
Host
Mouse
969
495
25
18
5
5
Clonality
Monoclonal
Conjugate
This HER2 antibody is un-conjugated
74
65
60
52
45
41
17
17
10
10
9
8
8
8
8
8
8
7
7
7
7
7
7
7
7
7
7
2
2
2
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
681
574
331
323
301
281
235
174
103
90
86
21
17
6
6
5
5
4
3
3
2
2
1
1
1
1
Supplier
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Catalog No. ABIN180510
$ 589.05
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008771965 ABIN180512 Func IP Mouse IgG1 Log in to see N28 3
0.0008771965 ABIN2661687 Func ICC FACS IF ICFC IP WB FITC Mouse IgG1 kappa Log in to see 24D2 6
0.0008771965 ABIN180511 Func IF IP Mouse IgG1 Extracellular Domain Log in to see N24
0.0008771965 ABIN180509 Func IP Mouse IgG1 Extracellular Domain Log in to see L26

Top referenced anti-HER2 antibody for Functional Studies

Similar anti-HER2 Antibodies

Application / Reactivity Human
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Dot Blot (DB) 192 Antibodies
ELISA 439 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 17 Antibodies
Flow Cytometry (FACS) 275 Antibodies
Functional Studies (Func) 5 Antibodies
Immunoassay (IA) 1 Antibodies
Immunochromatography (IC) 5 Antibodies
Immunocytochemistry (ICC) 86 Antibodies
Immunoelectron Microscopy (IEM) 6 Antibodies
Immunofluorescence (IF) 302 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 90 Antibodies
Immunohistochemistry (IHC) 329 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 5 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 2 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 3 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 104 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 235 Antibodies

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Epitope Extracellular Domain
(120), (83), (64), (54), (53), (53), (51), (44), (37), (36), (32), (29), (21), (20), (20), (20), (20), (19), (19), (19), (19), (19), (19), (18), (18), (18), (15), (14), (14), (14), (13), (13), (13), (12), (10), (10), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(1322), (418), (261), (24), (13), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Host Mouse
(969), (495), (25), (18), (5), (5)
Clonality (Clone)
Monoclonal   ( )
Conjugate This HER2 antibody is un-conjugated
(74), (65), (60), (52), (45), (41), (17), (17), (10), (10), (9), (8), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (2), (2), (2)
Application Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
(681), (574), (331), (323), (301), (281), (235), (174), (103), (90), (86), (21), (17), (6), (6), (5), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling References for anti-HER2 Antibody (ABIN180510) Images
Specificity This antibody detects c-erbB-2 / Her-2 / neu. It reacts with the intact cells( 1,2), shows moderate effect on c-erbB-2 internalization (1), slightly increases (~2-fold) the tyrosine kinase activity (1), and inhibits (~90 %) the tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2 (1,2,3). Does not react with Mouse and rat.
Characteristics Synonyms: HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19, Receptor tyrosine-protein kinase erbB-2,NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2
Purification Protein G chromatography
Immunogen Intact SKBR-3 breast cancer cells (1)Remarks: Epitope: Extracellular domain. Mol. Wt. of Antigen: 185 kDa.
Clone N12
Isotype IgG1

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling References for anti-HER2 Antibody (ABIN180510) Images back to top
Antigen
Alternative Name CD340 / ERBB2 / HER2 (ERBB2 Antibody Abstract)
Background C-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25 % of primary breast and ovarian tumors were found to overexpress the protein.Synonyms: HER-2, MNL19, NEU, NEU proto-oncogene, NGL, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, c-erbB-2, p185erbB2
Gene ID 2064
UniProt P04626
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling References for anti-HER2 Antibody (ABIN180510) Images back to top
Application Notes Inhibits Tumor Growth (approx. 90 % ) (1,2,3). Inhibits Cell Proliferation (1). Effect on c-erbB-2 Internalization (Moderate) (1,3). Electron Microscopy (2). Immunofluorescence. Immunohistology (Frozen only). Does not work in Immunoprecipitation. Positive Control: SKBR-3 cells, or breast carcinomas.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details References for anti-HER2 Antibody (ABIN180510) Images back to top
Concentration 1 mg/mL
Buffer 10 mM PBS, pH 7.4
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months

References for anti-HER2 Antibody (ABIN180510)

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
Background publications

Klapper, Vaisman, Hurwitz, Pinkas-Kramarski, Yarden, Sela: "A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors." in: Oncogene, Vol. 14, Issue 17, pp. 2099-109, 1997

Hurwitz, Stancovski, Sela, Yarden: "Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 8, pp. 3353-7, 1995

Stancovski, Hurwitz, Leitner, Ullrich, Yarden, Sela: "Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 19, pp. 8691-5, 1991