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|Antigen||Insulin Receptor-Related Receptor (INSRR) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This INSRR antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-INSRR AntibodyTarget Details INSRR Application Details Handling References for anti-INSRR antibody (ABIN359888) Images
|Specificity||This antibody reacts to INSRR (Insulin Receptor R).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human INSRR.|
Target Details INSRRProduct Details anti-INSRR Antibody Application Details Handling References for anti-INSRR antibody (ABIN359888) Images back to top
|Alternative Name||INSRR / IRR (INSRR Antibody Abstract)|
|Background||Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: INSR-related receptor, Insulin receptor-related protein|
|Gene ID||3645, 9606|
Application DetailsProduct Details anti-INSRR Antibody Target Details INSRR Handling References for anti-INSRR antibody (ABIN359888) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-INSRR Antibody Target Details INSRR Application Details References for anti-INSRR antibody (ABIN359888) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-INSRR antibody (ABIN359888)Product Details anti-INSRR Antibody Target Details INSRR Application Details Handling Images back to top
Whitmore, Maurer, Day, Jelmberg, Dasovich, Sundborg, Burkhead, Heipel, Madden, Kramer, Kuijper, Xu, Jaspers, Holly, Lok: "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 87, Issue 1-2, pp. 93-4, 2000
Shier, Watt: "Primary structure of a putative receptor for a ligand of the insulin family." in: The Journal of biological chemistry, Vol. 264, Issue 25, pp. 14605-8, 1989
Wehrenberg, Bloch, Chong-Li, Brazeau, Ling, Guillemin: "Pituitary response to growth hormone-releasing factor in rats with functional or anatomical lesions of the central nervous system that inhibit endogenous growth hormone secretion." in: Regulatory peptides, Vol. 8, Issue 1, pp. 1-8, 1984
Kracht, Hachmeister: "The demonstration of hormones in tissues by means of antibodies. Methodological problems in the use of immunohistological techniques for the localization of hormones." in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, Vol. 3, pp. Suppl 3:2-5, 1972
ImagesProduct Details anti-INSRR Antibody Target Details INSRR Application Details Handling References for anti-INSRR antibody (ABIN359888) back to top