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|Antigen||Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) Antibodies|
|Epitope||AA 163-514 Alternatives|
|Conjugate||This MST1R antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
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Product Details anti-MST1R AntibodyTarget Details MST1R Application Details Handling References for anti-MST1R antibody (ABIN453814) Images
|Specificity||This antibody recognizes CD136/RON.|
|Purification||Affinity Chromatography on Protein A|
|Immunogen||RON recombinant protein between amino acids 163-514 Genename: MST1R|
Target Details MST1RProduct Details anti-MST1R Antibody Application Details Handling References for anti-MST1R antibody (ABIN453814) Images back to top
|Alternative Name||CD136 / MST1R (MST1R Antibody Abstract)|
|Background||Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: MSP receptor, Macrophage-Stimulating 1 Receptor, Macrophage-stimulating protein receptor, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, PTK8, RON, p185-Ron|
Application DetailsProduct Details anti-MST1R Antibody Target Details MST1R Handling References for anti-MST1R antibody (ABIN453814) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MST1R Antibody Target Details MST1R Application Details References for anti-MST1R antibody (ABIN453814) Images back to top
|Buffer||PBS, 0.09 % (W/V) Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-MST1R antibody (ABIN453814)Product Details anti-MST1R Antibody Target Details MST1R Application Details Handling Images back to top
Maggiora, Lorenzato, Fracchioli, Costa, Castagnaro, Arisio, Katsaros, Massobrio, Comoglio, Flavia Di Renzo: "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness." in: Experimental cell research, Vol. 288, Issue 2, pp. 382-9, 2003
Santoro, Gaudino, Marchisio: "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration." in: Developmental cell, Vol. 5, Issue 2, pp. 257-71, 2003
Penengo, Rubin, Yarden, Gaudino: "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor." in: Oncogene, Vol. 22, Issue 24, pp. 3669-79, 2003
Zhou, He, Chen, Wang, Wang: "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential." in: Oncogene, Vol. 22, Issue 2, pp. 186-97, 2003
Danilkovitch-Miagkova, Duh, Kuzmin, Angeloni, Liu, Miller, Lerman: "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4580-5, 2003
ImagesProduct Details anti-MST1R Antibody Target Details MST1R Application Details Handling References for anti-MST1R antibody (ABIN453814) back to top