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anti-Mouse (Murine) NFAT1 Antibodies:
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Human Monoclonal NFAT1 Primary Antibody for ChIP, ELISA - ABIN152663
Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 8 Pubmed References
Dog (Canine) Monoclonal NFAT1 Primary Antibody for IF, IP - ABIN968123
Boise, Petryniak, Mao, June, Wang, Lindsten, Bravo, Kovary, Leiden, Thompson: The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. in Molecular and cellular biology 1993
Show all 5 Pubmed References
Dog (Canine) Monoclonal NFAT1 Primary Antibody for IF, IP - ABIN968124
Good, Maggirwar, Harhaj, Sun: Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. in The Journal of biological chemistry 1997
Show all 5 Pubmed References
Cow (Bovine) Polyclonal NFAT1 Primary Antibody for WB - ABIN2779960
Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. in Blood 2005
Show all 3 Pubmed References
Human Monoclonal NFAT1 Primary Antibody for IF, IP - ABIN967558
Crabtree: Contingent genetic regulatory events in T lymphocyte activation. in Science (New York, N.Y.) 1989
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Human Polyclonal NFAT1 Primary Antibody for IHC, IHC (p) - ABIN4339296
Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. in Cell death & disease 2015
Show all 2 Pubmed References
Human Polyclonal NFAT1 Primary Antibody for ELISA, IHC - ABIN4339294
Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. in Annals of the New York Academy of Sciences 2007
Human Polyclonal NFAT1 Primary Antibody for ICC, IF - ABIN4339295
Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. in Oncogene 2016
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (show NFKB1 Antibodies)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (show CD4 Antibodies)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Antibodies) in mouse islets enhanced insulin (show INS Antibodies) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Antibodies) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Antibodies)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Antibodies)(+)/CD8 (show CD8A Antibodies)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis
NFAT (show NFATC1 Antibodies) directs signaling enzymes to gene promoters in islets.
FOXP3 (show FOXP3 Antibodies) can inhibit NFAT (show NFATC1 Antibodies) driven expression of CD40L (show CD40LG Antibodies) and IL-17 (show IL17A Antibodies) in CD4 (show CD4 Antibodies) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
our findings reveal a new signaling pathway in microglia that couples TLR4 (show TLR4 Antibodies) activation with the translocation of NFAT1 into mitochondria to control the microglial activation during brain infection.
An interaction of NFAT1 and the beta-catenin (show CTNNB1 Antibodies) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (show CTNNB1 Antibodies)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (show CA2 Antibodies)+ microdomains, whereas NFAT4 (show NFATC3 Antibodies) additionally requires Ca2 (show CA2 Antibodies)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
revealed more than 170 NFAT (show NFATC1 Antibodies)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Antibodies) and NFATc2 in T cells, such as Raptor (show RPTOR Antibodies), CHEK1 (show CHEK1 Antibodies), CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros (show IKZF1 Antibodies), and Helios (show ZNFN1A2 Antibodies).
NFAT1 silencing could suppress cell migration and invasion through MMP-3 (show MMP3 Antibodies).
FOXP1 (show FOXP1 Antibodies) has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity.
we describe a novel mechanism by which GSK-3beta (show GSK3b Antibodies) fine-tunes NFATc2 and STAT3 (show STAT3 Antibodies) transcriptional networks to integrate upstream signaling events that govern pancreatic cancer progression and growth.
Up-regulation of Store-operated Ca2 (show CA2 Antibodies)+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells.
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
, nuclear factor of activated T-cells, cytoplasmic 2-like
, NFAT pre-existing subunit
, T-cell transcription factor NFAT1
, nuclear factor of activated T-cells, cytoplasmic 2
, NFAT transcription complex, preexisting component
, T cell transcription factor NFAT1
, nuclear factor of activated T-cells, preexisting component
, preexisting nuclear factor of activated T-cells 2