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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||5 Antibodies||41 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||2 Antibodies|
|Gel Shift (GS)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||33 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||26 Antibodies|
|Chromatin Immunoprecipitation (ChIP)||1 Antibodies|
|Dot Blot (DB)||19 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Antigen||Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antibodies|
|Epitope||AA 433-567 Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This NFAT1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-NFAT1 AntibodyTarget Details NFAT1 Application Details Handling References for anti-NFAT1 Antibody (ABIN967558) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human NF-ATc2 aa. 433-567 Peptide|
Target Details NFAT1Product Details anti-NFAT1 Antibody Application Details Handling References for anti-NFAT1 Antibody (ABIN967558) Images back to top
|Alternative Name||NF-ATc2 (NFAT1 Antibody Abstract)|
The NF-AT family of transcription factors are regulators of early immune response genes in T cells following their activation by CD40L, FasL and interleukins including IL-2, -3, -4 and -5. NF-AT proteins function in both signal transduction and transcription control. The DNA binding, active NF-AT complex contains a cytoplasmic, Ca2+/calcineurin dependent, cyclosporin sensitive subunit, designated NF-ATc, which is present in the cytoplasm of resting cells. Upon cell activation, NF-ATc is dephosphorylated and thus activated by calcineurin, resulting in rapid translocation of NF-ATc to the nucleus. The active NF-AT complex also contains a nuclear component, designated NF-ATn. In vitro, NF-AT cooperates with the mitogenic transcription factor AP-1 to induce multiple cytokine genes. NF-ATc is encoded by four genes: NF-ATc1 (originally named NF-ATc), NF-ATc2 (originally named NF-ATp), NF-ATc3 (NF-AT3), and NF-ATc4 (NF-AT4). These proteins are differentially expressed in tissues, suggesting that each may activate distinct sets of genes. NF-ATc2 is constutively expressed in resting immune cells. NF-ATc2 is required for the development of Th2 responses and plays a role in the production of IL-4.
Synonyms: NFAT1, NFATP, KIAA0611
|Molecular Weight||97-135 kDa|
|Pathways||RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-NFAT1 Antibody Target Details NFAT1 Handling References for anti-NFAT1 Antibody (ABIN967558) Images back to top
Related Products: ABIN968537, ABIN967389, ABIN968123
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFAT1 Antibody Target Details NFAT1 Application Details References for anti-NFAT1 Antibody (ABIN967558) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-NFAT1 Antibody (ABIN967558)Product Details anti-NFAT1 Antibody Target Details NFAT1 Application Details Handling Images back to top
|Product cited in:||
Xanthoudakis, Viola, Shaw et al.: "An enhanced immune response in mice lacking the transcription factor NFAT1." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 892-5, 1996 (PubMed).
Crabtree: "Contingent genetic regulatory events in T lymphocyte activation." in: Science (New York, N.Y.), Vol. 243, Issue 4889, pp. 355-61, 1989 (PubMed).
ImagesProduct Details anti-NFAT1 Antibody Target Details NFAT1 Application Details Handling References for anti-NFAT1 Antibody (ABIN967558) back to top