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|Antigen||P21-Activated Kinase 4 (PAK4) Antibodies|
|Reactivity||Hamster, Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PAK4 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-PAK4 AntibodyTarget Details PAK4 Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412865|
The antibody recognizes ~60-70 kDa Pak4 in samples of human, mouse, and rat origins.
The antibody does not cross-react with other Paks.
Reactivity to other species has not been tested.
|Cross-Reactivity (Details)||Does not cross-react with other Paks.|
|Immunogen||Synthetic peptide corresponding to the N-terminus of human Pak4|
Target Details PAK4Product Details anti-PAK4 Antibody Application Details Handling Images back to top
|Alternative Name||PAK4 (PAK4 Antibody Abstract)|
The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region. It has been demonstrated that phosphorylation of serine 474 of PAK4 may play a pivotal role in the activity and function of PAK4 kinase
Synonyms: PAK-4 , KIAA1142
|Research Area||Cancer, Cell Cycle, Cytoskeleton, Microfilaments, Apoptosis/Necrosis, Kinases/Phosphatases|
Application DetailsProduct Details anti-PAK4 Antibody Target Details PAK4 Handling Images back to top
|Application Notes||Western blot analysis (0.5-4 μg/mL). However, the optimal conditions should be determined individually. The antibody recognizes ~60-70 kDa Pak4 in samples of human, mouse, and rat origins. The antibody does not cross-react with other Paks. Reactivity to other species has not been tested.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PAK4 Antibody Target Details PAK4 Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti-PAK4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-PAK4 Antibody Target Details PAK4 Application Details Handling back to top