We are preparing the requested document. Please wait, this may take a while...!
|Antigen||P21-Activated Kinase 4 (PAK4) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PAK4 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-PAK4 AntibodyTarget Details PAK4 Application Details Handling Images
|Specificity||The antibody recognizes 72 kDa Pak4. It does not cross-react with other Paks.|
|Purification||Antigen affinity purified|
|Immunogen||Synthetic peptide corresponding to the N-terminus of human Pak4|
Target Details PAK4Product Details anti-PAK4 Antibody Application Details Handling Images back to top
|Alternative Name||PAK4 (PAK4 Antibody Abstract)|
|Background||The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region. It has been demonstrated that phosphorylation of serine 474 of PAK4 may play a pivotal role in the activity and function of PAK4 kinase.Synonyms: KIAA1142, PAK 4, PAK-4, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4|
|Research Area||Cancer, Cell Cycle, Cytoskeleton, Microfilaments, Apoptosis/Necrosis, Kinases/Phosphatases|
Application DetailsProduct Details anti-PAK4 Antibody Target Details PAK4 Handling Images back to top
Western Blot: 1 μg/mL. Immunoprecipitation: 20 μg/mL. Immunohistochemistry: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PAK4 Antibody Target Details PAK4 Application Details Images back to top
|Buffer||PBS containing 50 % glycerol, 1 % BSA, and 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||-20 °C/-80 °C|
|Storage Comment||Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.|